Nornidulin, A New Inhibitor of Plasmodium falciparum Malate:Quinone Oxidoreductase (PfMQO) from Indonesian Aspergillus sp. BioMCC f.T.8501

• Main Authors: Alfian Wika Cahyono, -, Loeki Enggar Fitri, -, Sri Winarsih, -, Erwahyuni Endang Prabandari, -, Danang Waluyo, -, Amila Pramisandi, -, Evita Chrisnayanti, -, Diana Dewi, -, Eka Siska, -, Nurlaila, -, Nuki Bambang Nugroho, -, Tomoyoshi Nozaki, -, Suciati, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: Multidisciplinary Digital Publishing Institute (MDPI) 2023
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/125059/1/C-15_Artikel.pdf; https://repository.unair.ac.id/125059/2/C-15%20kualitas%20karil%20dan%20validasi%20kadep.pdf; https://repository.unair.ac.id/125059/3/C-15_Similarity.pdf; https://repository.unair.ac.id/125059/; https://www.mdpi.com/1424-8247/16/2/268; https://doi.org/10.3390/ph16020268
• Institution: Universitas Airlangga

This study aimed to obtain a microbial active compound as a novel antimalarial drug from Indonesian isolates. Target-based assays were used to screen for antimalarial activity against the parasite mitochondrial, Plasmodium falciparum malate:quinone oxidoreductase (PfMQO) enzyme. In total, 1600 crude...