Non-Toxic Fractions of Streptomyces hygroscopicus Subsp. Hygroscopicus Metabolite Suppressed the Growth of Plasmodium falciparum in Vitro Possibly through L-malate: Quinone Oxidoreductase (PfMQO) Mitochondrial Enzyme Inhibition

• Main Authors: Alfian Wika Cahyono, -, Loeki Enggar Fitri, -, Nafisatuzzamrudah, -, Rivo Yudhinata Brian Nugraha, -, Rara Aulia, -, Fitria Febriliani, -, Dio Giovanni Ariel, -, Kana Mardhiyyah, -, Sri Winarsih, -, Suciati, -, Dian Japany, -, Erwahyuni Endang, -, Danang Waluyo, -
• Format: Article PeerReviewed
• Language: English; English; English
• Published: EManuscript Technologies 2020
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica; RS200-201 Pharmaceutical dosage forms
• Online Access: https://repository.unair.ac.id/125061/1/C-17_Artikel.pdf; https://repository.unair.ac.id/125061/2/C-17%20kualitas%20karil%20dan%20validasi%20kadep.pdf; https://repository.unair.ac.id/125061/3/C-17_Similarity.pdf; https://repository.unair.ac.id/125061/; https://www.sysrevpharm.org/abstract/nontoxic-fractions-of-streptomyces-hygroscopicus-subsp-hygroscopicus-metabolite-suppressed-the-growth-of-plasmodium-falc-66370.html; http://dx.doi.org/10.31838/srp.2020.10.79
• Institution: Universitas Airlangga

Introduction: Previous research has proven that ethyl acetate extract of Streptomyces hygroscopicus can inhibit Plasmodium growth in vivo and in vitro through inhibition of the Proteasome ubiquitin system. In this study, we analyzed the activity of several fractions of S. hygroscopicus toward the gr...