Soluble CD163 and small dense LDL cholesterol levels in type 2 diabetes patients
Introduction: The sdLDL cholesterol proportion is a better marker for the prediction of cardiovascular diseases (CVDs). Macrophages play a crucial role in both initiation and progression of atherosclerosis, the underlying mechanism of CVDs. This study investigated the correlation between soluble C...
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| Main Authors: | , , |
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| Format: | Article PeerReviewed |
| Language: | English English English English |
| Published: |
Academia Nacional de Medicina
2021
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| Online Access: | https://repository.unair.ac.id/127225/1/C-06%20Artikel.pdf https://repository.unair.ac.id/127225/2/C-06%20karil.pdf https://repository.unair.ac.id/127225/3/C-06%20Koresponding.pdf https://repository.unair.ac.id/127225/4/C-06%20turnitin.pdf https://repository.unair.ac.id/127225/ http://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/22913/144814489203 |
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| Institution: | Universitas Airlangga |
| Language: | English English English English |
| Summary: | Introduction: The sdLDL cholesterol proportion is a better marker for the prediction of cardiovascular diseases (CVDs). Macrophages play a crucial role in both initiation and progression of atherosclerosis, the underlying mechanism of CVDs. This study investigated the correlation between soluble CD163 as a biomarker macrophage activation and sdLDL cholesterol in type 2 diabetes mellitus (T2DM) subjects for the first time.
Methods: This study was an observational analytic cross-sectional study involved 40 patients with T2DM in Surabaya, Indonesia. The sdLDL was measured using a direct enzymatic colorimetric method using Architect c8000. The levels of sCD163 were measured by a quantitative enzyme immunoassay technique using a specific monoclonal antibody for human CD163 using Quantikine Elisa produced by R&D Systems Inc., USA.
Results: The average level of HbA1c in this study was 8.01 ± 1.39 %, and more than half of the subjects had HbA1c levels >8 % that revealed most of the patients in this study were in poor glycemic control. The average sdLDL cholesterol level in this study was 40.80 ± 19.14 mg/dL, and the mean of soluble CD163 was 741.22 ± 41.55 ng/mL. There were no differences in gender (male or female), glycemic control (<8 % vs >8 %), hypertension, and smoking on sCD163 levels and sdLDL cholesterol levels. We found a positive correlation between the soluble CD163 level with sdLDL (r=0.440, p=0.004).
Conclusion: The atherogenic lipoprotein fraction sdLDL cholesterol level correlated with soluble CD163 level. This could be a new link between lipid dysregulation, innate immunity, and atherosclerosis in T2DM. |
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