Soluble CD163 and small dense LDL cholesterol levels in type 2 diabetes patients

Introduction: The sdLDL cholesterol proportion is a better marker for the prediction of cardiovascular diseases (CVDs). Macrophages play a crucial role in both initiation and progression of atherosclerosis, the underlying mechanism of CVDs. This study investigated the correlation between soluble C...

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Main Authors: Hermina Novida, -, Soebagijo Adi Soelistijo, -, Ari Sutjahjo, -
Format: Article PeerReviewed
Language:English
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Published: Academia Nacional de Medicina 2021
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Online Access:https://repository.unair.ac.id/127225/1/C-06%20Artikel.pdf
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spelling id-langga.1272252023-06-13T07:44:10Z https://repository.unair.ac.id/127225/ Soluble CD163 and small dense LDL cholesterol levels in type 2 diabetes patients Hermina Novida, - Soebagijo Adi Soelistijo, - Ari Sutjahjo, - RC31-1245 Internal medicine Introduction: The sdLDL cholesterol proportion is a better marker for the prediction of cardiovascular diseases (CVDs). Macrophages play a crucial role in both initiation and progression of atherosclerosis, the underlying mechanism of CVDs. This study investigated the correlation between soluble CD163 as a biomarker macrophage activation and sdLDL cholesterol in type 2 diabetes mellitus (T2DM) subjects for the first time. Methods: This study was an observational analytic cross-sectional study involved 40 patients with T2DM in Surabaya, Indonesia. The sdLDL was measured using a direct enzymatic colorimetric method using Architect c8000. The levels of sCD163 were measured by a quantitative enzyme immunoassay technique using a specific monoclonal antibody for human CD163 using Quantikine Elisa produced by R&D Systems Inc., USA. Results: The average level of HbA1c in this study was 8.01 ± 1.39 %, and more than half of the subjects had HbA1c levels >8 % that revealed most of the patients in this study were in poor glycemic control. The average sdLDL cholesterol level in this study was 40.80 ± 19.14 mg/dL, and the mean of soluble CD163 was 741.22 ± 41.55 ng/mL. There were no differences in gender (male or female), glycemic control (<8 % vs >8 %), hypertension, and smoking on sCD163 levels and sdLDL cholesterol levels. We found a positive correlation between the soluble CD163 level with sdLDL (r=0.440, p=0.004). Conclusion: The atherogenic lipoprotein fraction sdLDL cholesterol level correlated with soluble CD163 level. This could be a new link between lipid dysregulation, innate immunity, and atherosclerosis in T2DM. Academia Nacional de Medicina 2021 Article PeerReviewed text en https://repository.unair.ac.id/127225/1/C-06%20Artikel.pdf text en https://repository.unair.ac.id/127225/2/C-06%20karil.pdf text en https://repository.unair.ac.id/127225/3/C-06%20Koresponding.pdf text en https://repository.unair.ac.id/127225/4/C-06%20turnitin.pdf Hermina Novida, - and Soebagijo Adi Soelistijo, - and Ari Sutjahjo, - (2021) Soluble CD163 and small dense LDL cholesterol levels in type 2 diabetes patients. Gaceta Médica de Caracas, 129 (2s). s305-s312. ISSN 0367-4762 http://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/22913/144814489203
institution Universitas Airlangga
building Universitas Airlangga Library
continent Asia
country Indonesia
Indonesia
content_provider Universitas Airlangga Library
collection UNAIR Repository
language English
English
English
English
topic RC31-1245 Internal medicine
spellingShingle RC31-1245 Internal medicine
Hermina Novida, -
Soebagijo Adi Soelistijo, -
Ari Sutjahjo, -
Soluble CD163 and small dense LDL cholesterol levels in type 2 diabetes patients
description Introduction: The sdLDL cholesterol proportion is a better marker for the prediction of cardiovascular diseases (CVDs). Macrophages play a crucial role in both initiation and progression of atherosclerosis, the underlying mechanism of CVDs. This study investigated the correlation between soluble CD163 as a biomarker macrophage activation and sdLDL cholesterol in type 2 diabetes mellitus (T2DM) subjects for the first time. Methods: This study was an observational analytic cross-sectional study involved 40 patients with T2DM in Surabaya, Indonesia. The sdLDL was measured using a direct enzymatic colorimetric method using Architect c8000. The levels of sCD163 were measured by a quantitative enzyme immunoassay technique using a specific monoclonal antibody for human CD163 using Quantikine Elisa produced by R&D Systems Inc., USA. Results: The average level of HbA1c in this study was 8.01 ± 1.39 %, and more than half of the subjects had HbA1c levels >8 % that revealed most of the patients in this study were in poor glycemic control. The average sdLDL cholesterol level in this study was 40.80 ± 19.14 mg/dL, and the mean of soluble CD163 was 741.22 ± 41.55 ng/mL. There were no differences in gender (male or female), glycemic control (<8 % vs >8 %), hypertension, and smoking on sCD163 levels and sdLDL cholesterol levels. We found a positive correlation between the soluble CD163 level with sdLDL (r=0.440, p=0.004). Conclusion: The atherogenic lipoprotein fraction sdLDL cholesterol level correlated with soluble CD163 level. This could be a new link between lipid dysregulation, innate immunity, and atherosclerosis in T2DM.
format Article
PeerReviewed
author Hermina Novida, -
Soebagijo Adi Soelistijo, -
Ari Sutjahjo, -
author_facet Hermina Novida, -
Soebagijo Adi Soelistijo, -
Ari Sutjahjo, -
author_sort Hermina Novida, -
title Soluble CD163 and small dense LDL cholesterol levels in type 2 diabetes patients
title_short Soluble CD163 and small dense LDL cholesterol levels in type 2 diabetes patients
title_full Soluble CD163 and small dense LDL cholesterol levels in type 2 diabetes patients
title_fullStr Soluble CD163 and small dense LDL cholesterol levels in type 2 diabetes patients
title_full_unstemmed Soluble CD163 and small dense LDL cholesterol levels in type 2 diabetes patients
title_sort soluble cd163 and small dense ldl cholesterol levels in type 2 diabetes patients
publisher Academia Nacional de Medicina
publishDate 2021
url https://repository.unair.ac.id/127225/1/C-06%20Artikel.pdf
https://repository.unair.ac.id/127225/2/C-06%20karil.pdf
https://repository.unair.ac.id/127225/3/C-06%20Koresponding.pdf
https://repository.unair.ac.id/127225/4/C-06%20turnitin.pdf
https://repository.unair.ac.id/127225/
http://saber.ucv.ve/ojs/index.php/rev_gmc/article/view/22913/144814489203
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