Adiponectin, anthropometric measurements and insulin resistance in adolescence with obesity
ABSTRACT Introduction: Obesity in adolescents can cause metabolic syndrome. Insulin resistance increases the risk of metabolic syndrome, which then increases the risk of premature death. Studies about anthropometric measurements and adiponectin levels as early markers of insulin resistance in ob...
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| Main Authors: | , , , , , |
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| Format: | Article PeerReviewed |
| Language: | English Indonesian English |
| Published: |
Persatuan Pemakanan Malaysia
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| Subjects: | |
| Online Access: | https://repository.unair.ac.id/127368/1/04.%20artikel.pdf https://repository.unair.ac.id/127368/2/04.pdf https://repository.unair.ac.id/127368/3/04.%20turnitin.pdf https://repository.unair.ac.id/127368/ https://nutriweb.org.my/mjn/publication/26-2/Vol%2026(2)%203.%20mjn.2019.0100%20Rendi%20(online%20first)%20updated.pdf https://doi.org/10.31246/mjn-2019-0100 |
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| Institution: | Universitas Airlangga |
| Language: | English Indonesian English |
| Summary: | ABSTRACT
Introduction: Obesity in adolescents can cause metabolic syndrome. Insulin
resistance increases the risk of metabolic syndrome, which then increases the risk
of premature death. Studies about anthropometric measurements and adiponectin
levels as early markers of insulin resistance in obese adolescents are still limited.
Methods: A cross-sectional study was performed on 59 obese adolescents aged
13–16 years. Obesity was established on the basis of the Centers for Disease Control
and Prevention (CDC) curve (2000). Insulin and blood glucose level measurements
were carried out using an enzymatic kit. Adiponectin levels were assayed using
enzyme-linked immunosorbent assay (ELISA). The relationships between variables
were evaluated by correlation analysis using SPSS. Results: Statistical tests
showed a positive correlation between waist circumference (r=0.421; p=0.001) and
Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) (r=0.396; p=0.002).
Waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) had a weak positive
correlation with insulin (r=0.343; p=0.008 and r=0.311; p=0.017) and HOMA-IR
(r=0.306; p=0.018). There was a weak negative correlation between adiponectin
and insulin in obese adolescents (r=-0.278; p=0.033). Conclusion: Anthropometric
measurements (waist circumference, WHR and WHtR) and adiponectin can be used
for early detection of insulin resistance and hyperinsulinemia in obese adolescents. |
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