Adiponectin, anthropometric measurements and insulin resistance in adolescence with obesity
ABSTRACT Introduction: Obesity in adolescents can cause metabolic syndrome. Insulin resistance increases the risk of metabolic syndrome, which then increases the risk of premature death. Studies about anthropometric measurements and adiponectin levels as early markers of insulin resistance in ob...
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id-langga.1273682023-06-15T02:32:48Z https://repository.unair.ac.id/127368/ Adiponectin, anthropometric measurements and insulin resistance in adolescence with obesity Nur Aisiyah Widjaja, - Rendi Aji Prihaningtyas, - Meta Herdiana Hanindita, - Roedi Irawan, - IDG Ugrasena, - Retno Handajani, - R5-920 Medicine (General) ABSTRACT Introduction: Obesity in adolescents can cause metabolic syndrome. Insulin resistance increases the risk of metabolic syndrome, which then increases the risk of premature death. Studies about anthropometric measurements and adiponectin levels as early markers of insulin resistance in obese adolescents are still limited. Methods: A cross-sectional study was performed on 59 obese adolescents aged 13–16 years. Obesity was established on the basis of the Centers for Disease Control and Prevention (CDC) curve (2000). Insulin and blood glucose level measurements were carried out using an enzymatic kit. Adiponectin levels were assayed using enzyme-linked immunosorbent assay (ELISA). The relationships between variables were evaluated by correlation analysis using SPSS. Results: Statistical tests showed a positive correlation between waist circumference (r=0.421; p=0.001) and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) (r=0.396; p=0.002). Waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) had a weak positive correlation with insulin (r=0.343; p=0.008 and r=0.311; p=0.017) and HOMA-IR (r=0.306; p=0.018). There was a weak negative correlation between adiponectin and insulin in obese adolescents (r=-0.278; p=0.033). Conclusion: Anthropometric measurements (waist circumference, WHR and WHtR) and adiponectin can be used for early detection of insulin resistance and hyperinsulinemia in obese adolescents. Persatuan Pemakanan Malaysia Article PeerReviewed text en https://repository.unair.ac.id/127368/1/04.%20artikel.pdf text id https://repository.unair.ac.id/127368/2/04.pdf text en https://repository.unair.ac.id/127368/3/04.%20turnitin.pdf Nur Aisiyah Widjaja, - and Rendi Aji Prihaningtyas, - and Meta Herdiana Hanindita, - and Roedi Irawan, - and IDG Ugrasena, - and Retno Handajani, - Adiponectin, anthropometric measurements and insulin resistance in adolescence with obesity. Malaysian Journal of Nutrition., 26 (2). pp. 165-172. ISSN 1394-035X https://nutriweb.org.my/mjn/publication/26-2/Vol%2026(2)%203.%20mjn.2019.0100%20Rendi%20(online%20first)%20updated.pdf https://doi.org/10.31246/mjn-2019-0100 |
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R5-920 Medicine (General) Nur Aisiyah Widjaja, - Rendi Aji Prihaningtyas, - Meta Herdiana Hanindita, - Roedi Irawan, - IDG Ugrasena, - Retno Handajani, - Adiponectin, anthropometric measurements and insulin resistance in adolescence with obesity |
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ABSTRACT
Introduction: Obesity in adolescents can cause metabolic syndrome. Insulin
resistance increases the risk of metabolic syndrome, which then increases the risk
of premature death. Studies about anthropometric measurements and adiponectin
levels as early markers of insulin resistance in obese adolescents are still limited.
Methods: A cross-sectional study was performed on 59 obese adolescents aged
13–16 years. Obesity was established on the basis of the Centers for Disease Control
and Prevention (CDC) curve (2000). Insulin and blood glucose level measurements
were carried out using an enzymatic kit. Adiponectin levels were assayed using
enzyme-linked immunosorbent assay (ELISA). The relationships between variables
were evaluated by correlation analysis using SPSS. Results: Statistical tests
showed a positive correlation between waist circumference (r=0.421; p=0.001) and
Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) (r=0.396; p=0.002).
Waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) had a weak positive
correlation with insulin (r=0.343; p=0.008 and r=0.311; p=0.017) and HOMA-IR
(r=0.306; p=0.018). There was a weak negative correlation between adiponectin
and insulin in obese adolescents (r=-0.278; p=0.033). Conclusion: Anthropometric
measurements (waist circumference, WHR and WHtR) and adiponectin can be used
for early detection of insulin resistance and hyperinsulinemia in obese adolescents. |
format |
Article PeerReviewed |
author |
Nur Aisiyah Widjaja, - Rendi Aji Prihaningtyas, - Meta Herdiana Hanindita, - Roedi Irawan, - IDG Ugrasena, - Retno Handajani, - |
author_facet |
Nur Aisiyah Widjaja, - Rendi Aji Prihaningtyas, - Meta Herdiana Hanindita, - Roedi Irawan, - IDG Ugrasena, - Retno Handajani, - |
author_sort |
Nur Aisiyah Widjaja, - |
title |
Adiponectin, anthropometric measurements and insulin resistance in adolescence with obesity |
title_short |
Adiponectin, anthropometric measurements and insulin resistance in adolescence with obesity |
title_full |
Adiponectin, anthropometric measurements and insulin resistance in adolescence with obesity |
title_fullStr |
Adiponectin, anthropometric measurements and insulin resistance in adolescence with obesity |
title_full_unstemmed |
Adiponectin, anthropometric measurements and insulin resistance in adolescence with obesity |
title_sort |
adiponectin, anthropometric measurements and insulin resistance in adolescence with obesity |
publisher |
Persatuan Pemakanan Malaysia |
url |
https://repository.unair.ac.id/127368/1/04.%20artikel.pdf https://repository.unair.ac.id/127368/2/04.pdf https://repository.unair.ac.id/127368/3/04.%20turnitin.pdf https://repository.unair.ac.id/127368/ https://nutriweb.org.my/mjn/publication/26-2/Vol%2026(2)%203.%20mjn.2019.0100%20Rendi%20(online%20first)%20updated.pdf https://doi.org/10.31246/mjn-2019-0100 |
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1769840103374454784 |