A new copper (II)-imidazole derivative effectively inhibits replication of denv-2 in vero cell
Background: Dengue is a kind of infectious disease that was distributed in the tropical and sub-tropical areas. To date, there is no clinically approved dengue vaccine or antiviral for humans, even though there have been great efforts towards this end. Therefore, finding the effective compound again...
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Main Authors: | , , , , , , , , , |
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Format: | Article PeerReviewed |
Language: | English English English |
Published: |
Obafemi Awolowo University
2018
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Subjects: | |
Online Access: | https://repository.unair.ac.id/127534/1/C14.%20Fulltext_r.pdf https://repository.unair.ac.id/127534/2/C14.%20Penilaian%20dan%20Validasi.pdf https://repository.unair.ac.id/127534/3/C14.%20Similarity.pdf https://repository.unair.ac.id/127534/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876766/ |
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Institution: | Universitas Airlangga |
Language: | English English English |
Summary: | Background: Dengue is a kind of infectious disease that was distributed in the tropical and sub-tropical areas. To date, there is no clinically approved dengue vaccine or antiviral for humans, even though there have been great efforts towards this end. Therefore, finding the effective compound against dengue virus (DENV) replication is very important. Among the complex compounds, copper(II)-imidazole derivatives are of interest because of their biological
and medicinal benefits.
Materials and Methods: In the present study, antiviral activity of [Cu(2,4,5-triphenylimidazole) 2]n, was evaluated
against different stages of dengue virus type 2 (DENV-2) replication in Vero cell using focus forming unit reduction
assay and quantitative ELISA.
Results: [Cu(2,4,5-triphenylimidazole) 2]n inhibited DENV-2 replication in Vero cells with IC 50 = 2.3 μg/ml and SI= 19.42 when cells were treated 2 days after virus infection, whereas its CC 50 for cytotoxicity to Vero cells was 44.174 μg/ml.
Conclusion: The compound has high anti-DENV2 activity, less toxicity, and a high possibility to be considered a drug
candidate. |
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