A new copper (II)-imidazole derivative effectively inhibits replication of denv-2 in vero cell
Background: Dengue is a kind of infectious disease that was distributed in the tropical and sub-tropical areas. To date, there is no clinically approved dengue vaccine or antiviral for humans, even though there have been great efforts towards this end. Therefore, finding the effective compound again...
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Obafemi Awolowo University
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id-langga.1275342023-06-23T04:06:14Z https://repository.unair.ac.id/127534/ A new copper (II)-imidazole derivative effectively inhibits replication of denv-2 in vero cell Teguh Hari Sucipto, .- Siti Churrotin, .- Harsasi Setyawati, .- Fahimah Martak, .- Kris Cahyo Mulyatno, .- Ilham Harlan Amarullah, .- Tomohiro Kotaki, .- Masanori Kameoka, .- Subagyo Yotopranoto, .- Soegeng Soegijanto, .- Q Science QD Chemistry QD146-197 Inorganic chemistry Background: Dengue is a kind of infectious disease that was distributed in the tropical and sub-tropical areas. To date, there is no clinically approved dengue vaccine or antiviral for humans, even though there have been great efforts towards this end. Therefore, finding the effective compound against dengue virus (DENV) replication is very important. Among the complex compounds, copper(II)-imidazole derivatives are of interest because of their biological and medicinal benefits. Materials and Methods: In the present study, antiviral activity of [Cu(2,4,5-triphenylimidazole) 2]n, was evaluated against different stages of dengue virus type 2 (DENV-2) replication in Vero cell using focus forming unit reduction assay and quantitative ELISA. Results: [Cu(2,4,5-triphenylimidazole) 2]n inhibited DENV-2 replication in Vero cells with IC 50 = 2.3 μg/ml and SI= 19.42 when cells were treated 2 days after virus infection, whereas its CC 50 for cytotoxicity to Vero cells was 44.174 μg/ml. Conclusion: The compound has high anti-DENV2 activity, less toxicity, and a high possibility to be considered a drug candidate. Obafemi Awolowo University 2018 Article PeerReviewed text en https://repository.unair.ac.id/127534/1/C14.%20Fulltext_r.pdf text en https://repository.unair.ac.id/127534/2/C14.%20Penilaian%20dan%20Validasi.pdf text en https://repository.unair.ac.id/127534/3/C14.%20Similarity.pdf Teguh Hari Sucipto, .- and Siti Churrotin, .- and Harsasi Setyawati, .- and Fahimah Martak, .- and Kris Cahyo Mulyatno, .- and Ilham Harlan Amarullah, .- and Tomohiro Kotaki, .- and Masanori Kameoka, .- and Subagyo Yotopranoto, .- and Soegeng Soegijanto, .- (2018) A new copper (II)-imidazole derivative effectively inhibits replication of denv-2 in vero cell. African Journal of Infectious Diseases, 12 (1). pp. 116-119. ISSN 20060165 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876766/ |
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Q Science QD Chemistry QD146-197 Inorganic chemistry Teguh Hari Sucipto, .- Siti Churrotin, .- Harsasi Setyawati, .- Fahimah Martak, .- Kris Cahyo Mulyatno, .- Ilham Harlan Amarullah, .- Tomohiro Kotaki, .- Masanori Kameoka, .- Subagyo Yotopranoto, .- Soegeng Soegijanto, .- A new copper (II)-imidazole derivative effectively inhibits replication of denv-2 in vero cell |
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Background: Dengue is a kind of infectious disease that was distributed in the tropical and sub-tropical areas. To date, there is no clinically approved dengue vaccine or antiviral for humans, even though there have been great efforts towards this end. Therefore, finding the effective compound against dengue virus (DENV) replication is very important. Among the complex compounds, copper(II)-imidazole derivatives are of interest because of their biological
and medicinal benefits.
Materials and Methods: In the present study, antiviral activity of [Cu(2,4,5-triphenylimidazole) 2]n, was evaluated
against different stages of dengue virus type 2 (DENV-2) replication in Vero cell using focus forming unit reduction
assay and quantitative ELISA.
Results: [Cu(2,4,5-triphenylimidazole) 2]n inhibited DENV-2 replication in Vero cells with IC 50 = 2.3 μg/ml and SI= 19.42 when cells were treated 2 days after virus infection, whereas its CC 50 for cytotoxicity to Vero cells was 44.174 μg/ml.
Conclusion: The compound has high anti-DENV2 activity, less toxicity, and a high possibility to be considered a drug
candidate. |
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Article PeerReviewed |
author |
Teguh Hari Sucipto, .- Siti Churrotin, .- Harsasi Setyawati, .- Fahimah Martak, .- Kris Cahyo Mulyatno, .- Ilham Harlan Amarullah, .- Tomohiro Kotaki, .- Masanori Kameoka, .- Subagyo Yotopranoto, .- Soegeng Soegijanto, .- |
author_facet |
Teguh Hari Sucipto, .- Siti Churrotin, .- Harsasi Setyawati, .- Fahimah Martak, .- Kris Cahyo Mulyatno, .- Ilham Harlan Amarullah, .- Tomohiro Kotaki, .- Masanori Kameoka, .- Subagyo Yotopranoto, .- Soegeng Soegijanto, .- |
author_sort |
Teguh Hari Sucipto, .- |
title |
A new copper (II)-imidazole derivative effectively inhibits replication of denv-2 in vero cell |
title_short |
A new copper (II)-imidazole derivative effectively inhibits replication of denv-2 in vero cell |
title_full |
A new copper (II)-imidazole derivative effectively inhibits replication of denv-2 in vero cell |
title_fullStr |
A new copper (II)-imidazole derivative effectively inhibits replication of denv-2 in vero cell |
title_full_unstemmed |
A new copper (II)-imidazole derivative effectively inhibits replication of denv-2 in vero cell |
title_sort |
new copper (ii)-imidazole derivative effectively inhibits replication of denv-2 in vero cell |
publisher |
Obafemi Awolowo University |
publishDate |
2018 |
url |
https://repository.unair.ac.id/127534/1/C14.%20Fulltext_r.pdf https://repository.unair.ac.id/127534/2/C14.%20Penilaian%20dan%20Validasi.pdf https://repository.unair.ac.id/127534/3/C14.%20Similarity.pdf https://repository.unair.ac.id/127534/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5876766/ |
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1769840132122214400 |