Losartan Has a Comparable Effect to Human Recombinant ACE2 in Reducing Interleukin-6 (IL-6) Levels on Human Adipocytes Exposed to SARS-CoV-2 Spike Protein
BACKGROUND: High angiotensin-converting enzyme 2 (ACE2) expression in adipocyte cells facilitates the initiation of SARS-CoV-2 infection and triggers a cytokine storm. This finding suggests that obesity is an independent risk factor for the severity of the symptoms caused by COVID-19. The use...
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| Main Authors: | , , , , |
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| Format: | Article PeerReviewed |
| Language: | English English Indonesian Indonesian |
| Published: |
The Indonesia Biomedical Journal
2022
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| Subjects: | |
| Online Access: | https://repository.unair.ac.id/128445/1/21.%20Losartan%20has%20a%20Comparable.pdf https://repository.unair.ac.id/128445/3/21.%20Losartan%20has%20a%20Comparable.pdf https://repository.unair.ac.id/128445/11/19.karil.pdf https://repository.unair.ac.id/128445/12/19.%20korespondensi.pdf https://repository.unair.ac.id/128445/ https://inabj.org/index.php/ibj/article/view/2552/665 |
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| Institution: | Universitas Airlangga |
| Language: | English English Indonesian Indonesian |
| Summary: | BACKGROUND: High angiotensin-converting
enzyme 2 (ACE2) expression in adipocyte
cells facilitates the initiation of SARS-CoV-2
infection and triggers a cytokine storm. This finding
suggests that obesity is an independent risk factor for the
severity of the symptoms caused by COVID-19. The use
of cardiovascular medications that focus on ACE2, such
as angiotensin II receptor blockers, remains controversial,
and their effects on inflammatory cytokine production and
ACE2 expression in cells, especially adipocytes, remain
inconsistent. |
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