Losartan Has a Comparable Effect to Human Recombinant ACE2 in Reducing Interleukin-6 (IL-6) Levels on Human Adipocytes Exposed to SARS-CoV-2 Spike Protein

• Main Authors: Hanestya Oky Hermawan, -, Meity Ardiana, Meity, I Gde Rurus Suryawan, -, Primasitha Maharany Harsoyo, -, Muhammad Rafli, -
• Format: Article PeerReviewed
• Language: English; English; Indonesian; Indonesian
• Published: The Indonesia Biomedical Journal 2022
• Subjects: R5-920 Medicine (General)
• Online Access: https://repository.unair.ac.id/128445/1/21.%20Losartan%20has%20a%20Comparable.pdf; https://repository.unair.ac.id/128445/3/21.%20Losartan%20has%20a%20Comparable.pdf; https://repository.unair.ac.id/128445/11/19.karil.pdf; https://repository.unair.ac.id/128445/12/19.%20korespondensi.pdf; https://repository.unair.ac.id/128445/; https://inabj.org/index.php/ibj/article/view/2552/665
• Institution: Universitas Airlangga

BACKGROUND: High angiotensin-converting enzyme 2 (ACE2) expression in adipocyte cells facilitates the initiation of SARS-CoV-2 infection and triggers a cytokine storm. This finding suggests that obesity is an independent risk factor for the severity of the symptoms caused by COVID-19. The use...