Selenium level correlates negatively with antibodies but positively with thyroid function in children with down syndrome: an Indonesian study

Background: Children with Down syndrome (DS) are prone to developing autoimmune thyroid disease (AITD). Previous studies found lower selenium (Se) levels in children with AITD. Glutathione peroxidase-3 (GPx3) and selenoprotein-P (SePP) are widely used to measure Se levels. DS children tend to have l...

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Main Authors: Yuni Hisbiyah, -, Anang Endaryanto, -, Bagus Setyoboedi, Bagus, Nur Rochmah, -, Muhammad Faizi, -, Katherine Fedora, -
Format: Article PeerReviewed
Language:English
Indonesian
English
Published: Frontiers Media S.A.
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Online Access:https://repository.unair.ac.id/128516/1/03.%20Artikel.pdf
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https://www.frontiersin.org/articles/10.3389/fendo.2023.1177373/full
https://doi.org/10.3389/fendo.2023.1177373
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spelling id-langga.1285162023-10-26T01:51:02Z https://repository.unair.ac.id/128516/ Selenium level correlates negatively with antibodies but positively with thyroid function in children with down syndrome: an Indonesian study Yuni Hisbiyah, - Anang Endaryanto, - Bagus Setyoboedi, Bagus Nur Rochmah, - Muhammad Faizi, - Katherine Fedora, - R5-920 Medicine (General) Background: Children with Down syndrome (DS) are prone to developing autoimmune thyroid disease (AITD). Previous studies found lower selenium (Se) levels in children with AITD. Glutathione peroxidase-3 (GPx3) and selenoprotein-P (SePP) are widely used to measure Se levels. DS children tend to have lower Se levels, the main contributor to hypothyroidism in this population. This study aimed to analyze the Se’s role in AITD in Indonesian children with DS. Methods: This cross-sectional study was conducted between February 2021-June 2022 at the Pediatric Outpatient Clinic of Dr Soetomo Hospital. DS children aged 1 month to 18 years were enrolled using consecutive sampling. Thyroid-stimulating hormone, free thyroxine, thyroid peroxidase (TPO-Ab) and thyroglobulin (Tg-Ab) autoantibody, GPx3, and SePP levels were measured in plasma samples using enzyme-linked immunosorbent assays. Statistical analyses used Chi-square, Mann–Whitney, and Spearman’s rank correlation (rs). All results with p<0.05 were considered statistically significant. Results: Among 62 children with DS, SePP and GPx3 levels were significantly lower in those with AITD than those without AITD (p=0.013 and p=0.018, respectively). SePP and GPx3 levels correlated significantly with lower TPO-Ab (rs=−0.439 with p=1×10-5 and rs=−0.396 with p=0.001, respectively) and Tg-Ab (rs=−0.474 with p=1×10-5 and rs=−0.410 with p=0.001, respectively) levels. SePP levels correlated significantly with lower thyroid dysfunction incidence (rs=-0.252, p=0.048) in the AITD group. Conclusion: Selenium deficiency contributes to autoimmune process in the thyroid and to thyroid dysfunction in children with Down syndrome. Our findings recommend increasing Se levels through Se-containing foods to reduce the risks of AITD and thyroid dysfunction in DS children with AITD. Frontiers Media S.A. Article PeerReviewed text en https://repository.unair.ac.id/128516/1/03.%20Artikel.pdf text id https://repository.unair.ac.id/128516/2/03.%20karil.pdf text en https://repository.unair.ac.id/128516/3/03.%20turnitin.pdf Yuni Hisbiyah, - and Anang Endaryanto, - and Bagus Setyoboedi, Bagus and Nur Rochmah, - and Muhammad Faizi, - and Katherine Fedora, - Selenium level correlates negatively with antibodies but positively with thyroid function in children with down syndrome: an Indonesian study. Frontiers in Endocrinology, 14. ISSN 1664-2392 https://www.frontiersin.org/articles/10.3389/fendo.2023.1177373/full https://doi.org/10.3389/fendo.2023.1177373
institution Universitas Airlangga
building Universitas Airlangga Library
continent Asia
country Indonesia
Indonesia
content_provider Universitas Airlangga Library
collection UNAIR Repository
language English
Indonesian
English
topic R5-920 Medicine (General)
spellingShingle R5-920 Medicine (General)
Yuni Hisbiyah, -
Anang Endaryanto, -
Bagus Setyoboedi, Bagus
Nur Rochmah, -
Muhammad Faizi, -
Katherine Fedora, -
Selenium level correlates negatively with antibodies but positively with thyroid function in children with down syndrome: an Indonesian study
description Background: Children with Down syndrome (DS) are prone to developing autoimmune thyroid disease (AITD). Previous studies found lower selenium (Se) levels in children with AITD. Glutathione peroxidase-3 (GPx3) and selenoprotein-P (SePP) are widely used to measure Se levels. DS children tend to have lower Se levels, the main contributor to hypothyroidism in this population. This study aimed to analyze the Se’s role in AITD in Indonesian children with DS. Methods: This cross-sectional study was conducted between February 2021-June 2022 at the Pediatric Outpatient Clinic of Dr Soetomo Hospital. DS children aged 1 month to 18 years were enrolled using consecutive sampling. Thyroid-stimulating hormone, free thyroxine, thyroid peroxidase (TPO-Ab) and thyroglobulin (Tg-Ab) autoantibody, GPx3, and SePP levels were measured in plasma samples using enzyme-linked immunosorbent assays. Statistical analyses used Chi-square, Mann–Whitney, and Spearman’s rank correlation (rs). All results with p<0.05 were considered statistically significant. Results: Among 62 children with DS, SePP and GPx3 levels were significantly lower in those with AITD than those without AITD (p=0.013 and p=0.018, respectively). SePP and GPx3 levels correlated significantly with lower TPO-Ab (rs=−0.439 with p=1×10-5 and rs=−0.396 with p=0.001, respectively) and Tg-Ab (rs=−0.474 with p=1×10-5 and rs=−0.410 with p=0.001, respectively) levels. SePP levels correlated significantly with lower thyroid dysfunction incidence (rs=-0.252, p=0.048) in the AITD group. Conclusion: Selenium deficiency contributes to autoimmune process in the thyroid and to thyroid dysfunction in children with Down syndrome. Our findings recommend increasing Se levels through Se-containing foods to reduce the risks of AITD and thyroid dysfunction in DS children with AITD.
format Article
PeerReviewed
author Yuni Hisbiyah, -
Anang Endaryanto, -
Bagus Setyoboedi, Bagus
Nur Rochmah, -
Muhammad Faizi, -
Katherine Fedora, -
author_facet Yuni Hisbiyah, -
Anang Endaryanto, -
Bagus Setyoboedi, Bagus
Nur Rochmah, -
Muhammad Faizi, -
Katherine Fedora, -
author_sort Yuni Hisbiyah, -
title Selenium level correlates negatively with antibodies but positively with thyroid function in children with down syndrome: an Indonesian study
title_short Selenium level correlates negatively with antibodies but positively with thyroid function in children with down syndrome: an Indonesian study
title_full Selenium level correlates negatively with antibodies but positively with thyroid function in children with down syndrome: an Indonesian study
title_fullStr Selenium level correlates negatively with antibodies but positively with thyroid function in children with down syndrome: an Indonesian study
title_full_unstemmed Selenium level correlates negatively with antibodies but positively with thyroid function in children with down syndrome: an Indonesian study
title_sort selenium level correlates negatively with antibodies but positively with thyroid function in children with down syndrome: an indonesian study
publisher Frontiers Media S.A.
url https://repository.unair.ac.id/128516/1/03.%20Artikel.pdf
https://repository.unair.ac.id/128516/2/03.%20karil.pdf
https://repository.unair.ac.id/128516/3/03.%20turnitin.pdf
https://repository.unair.ac.id/128516/
https://www.frontiersin.org/articles/10.3389/fendo.2023.1177373/full
https://doi.org/10.3389/fendo.2023.1177373
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