Peranan Perasan Bawang Putih (Allium sativum Linn.) Sebagai Imunomodulator Terhadap Respon Inflamasi Pada Kulit Akibat Infeksi Staphylococcus aureus
Staphylococcus aureus, one of pathogens bacteria, causes many kinds of Staphylococcosis. Staphylococcal wound infections, could be then followed by abscesses and septicemia. Recently is also known Staphylococcosis caused by Methicillin-resistant S. aureus (MRSA), which could also infect both human a...
Saved in:
| Summary: | Staphylococcus aureus, one of pathogens bacteria, causes many kinds of Staphylococcosis. Staphylococcal wound infections, could be then followed by abscesses and septicemia. Recently is also known Staphylococcosis caused by Methicillin-resistant S. aureus (MRSA), which could also infect both human and animals. Recent study has showed the ability of Garlic (Allium sativum) as an antibacterial and immunomudulatory against Staphylococcal, which could also increase macrophage activity. Recent in vivo experimental study using a complete-randomized design was aimed to find out the effects of topical treatment of garlic juice due to staphylococcal skin inflammatory responses in mice (Mus Musculus), based on the number of inflammatory cells, such as neutrophils, macrophages that produces TNF-a, and IL-la. It was conducted for five days with eleven treatments, each with five replications: five groups of mice treated with garlic; five groups of untreated mice; and a negative control group. Neutrophils were observed using Hematoxylin Eosin staining (HE), whereas TNF-a and IL-la using Immunohistochemistry Test. The result showed significant differences between garlic juice-treated group and untreated group, by the decreasing of neutrophils and macrophage with IL-la in treated group. However, there were no significant differences in the number ofTNF-a macrophages. The conclusion of the study was topical therapy of garlic juice could be significantly decrease the cells number of neutrofil and macrophage that produces IL-la in staphylococcal skin wounds of mice (Mus Musculus), while it could not changed the number of macrophage that produces TNF-a. |
|---|