Potensi Dan Mekanisme Kerja Isoflavonoid Untuk Proteksi Sel Endothelium Pada Hiperkolesterolemia
Protective effect of isoflavonoid on endothelial celi were studied in cholesterol-fed rabbits. The cholesterol-rich diet markedly increased Malondialdehyde (MDA) in the plasma as reflected by Thiobarbituric Acid-Reactive Substances (TBARS), decreased cGMP and decreased endothelium-dependent vascular...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian |
| Published: |
2006
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| Subjects: | |
| Online Access: | https://repository.unair.ac.id/132101/1/sri%20agus%20sudjarwo20240201_14322515.pdf https://repository.unair.ac.id/132101/ http://www.lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian |
| Summary: | Protective effect of isoflavonoid on endothelial celi were studied in cholesterol-fed rabbits. The cholesterol-rich diet markedly increased Malondialdehyde (MDA) in the plasma as reflected by Thiobarbituric Acid-Reactive Substances (TBARS), decreased cGMP and decreased endothelium-dependent vascular relaxations to acetylcholine compared to vessels from normal rabbits. In cholesterol-fed rabbits, Isoflavonoid treatment decreased MDA in plasma production, increased cGMP and increased endothelium-dependent relaxations to acetylcholine.
These results suggest that dietary treatment of rabbits with isoflavonoid may prevent superoxide anion (0.2) induced inactivation of endothelium-dependent relaxing factor (EDRF), improve the endothelium-dependent relaxation to acetylcholine in the aortic blood vessels and increase cyclic GMP content in aortic cholesterol-fed rabbits. |
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