Potensi Dan Mekanisme Kerja Isoflavonoid Untuk Proteksi Sel Endothelium Pada Hiperkolesterolemia

• Main Authors: Sri Agus Sudjarwo, Widajat S
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian
• Published: 2006
• Subjects: RC Internal medicine
• Online Access: https://repository.unair.ac.id/132101/1/sri%20agus%20sudjarwo20240201_14322515.pdf; https://repository.unair.ac.id/132101/; http://www.lib.unair.ac.id
• Institution: Universitas Airlangga

Protective effect of isoflavonoid on endothelial celi were studied in cholesterol-fed rabbits. The cholesterol-rich diet markedly increased Malondialdehyde (MDA) in the plasma as reflected by Thiobarbituric Acid-Reactive Substances (TBARS), decreased cGMP and decreased endothelium-dependent vascular relaxations to acetylcholine compared to vessels from normal rabbits. In cholesterol-fed rabbits, Isoflavonoid treatment decreased MDA in plasma production, increased cGMP and increased endothelium-dependent relaxations to acetylcholine. These results suggest that dietary treatment of rabbits with isoflavonoid may prevent superoxide anion (0.2) induced inactivation of endothelium-dependent relaxing factor (EDRF), improve the endothelium-dependent relaxation to acetylcholine in the aortic blood vessels and increase cyclic GMP content in aortic cholesterol-fed rabbits.