A meta-analysis of alveolar bone grafting using bone substitutes in cleft lip and palate patients
Abstrac In individuals with cleft lip and palate (CLP), an alveolar bone graft (ABG) is carried out for alveolar cleft closure. Several sources for ABG include autologous bone, xenologous bone, and alloplastic substitutes. Autologous bone has been the preferred source for ABG. Alloplastic sub...
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| Main Author: | |
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| Format: | Article PeerReviewed |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024
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| Subjects: | |
| Online Access: | https://repository.unair.ac.id/134434/1/2.%20artikel%20karya%20ilmiah%20syarat%20khusus.pdf https://repository.unair.ac.id/134434/ https://journals.lww.com/tcmj/fulltext/2024/36010/a_meta_analysis_of_alveolar_bone_grafting_using.6.aspx |
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| Institution: | Universitas Airlangga |
| Language: | English |
| Summary: | Abstrac
In individuals with cleft lip and palate (CLP), an alveolar bone graft (ABG) is carried out
for alveolar cleft closure. Several sources for ABG include autologous bone, xenologous
bone, and alloplastic substitutes. Autologous bone has been the preferred source for ABG.
Alloplastic substitutes might serve as an alternative. This study aimed to compare the
outcomes between autologous and alloplastic as sources for ABG. This study made use of
eight web databases. Randomized control trials (RCTs) and non-RCTs were included. CLP
patients with alveolar cleft with imaging studies, computed tomography (CT scan) and/or cone
beam CT scan, and bone graft volume within 6–12 months postintervention were selected.
Bone graft volume within 6–12 months postintervention was assessed. Three studies met
the inclusion criteria. After 6–12 months of follow‑up, there were no statistically significant
differences in bone graft volume between autologous and alloplastic bone grafts (fixed‑effect
model estimate value = 0.21; confidence interval − 0.301–0.730; P = 0.414). The limitations
include small research sample sizes, a high likelihood of bias among included studies, and
different alloplastic materials from each included study. Autologous and alloplastic bone
grafts showed similar effectiveness in alveolar bone grafting. Further clinical trial studies with
bigger sample sizes and similar interventions are needed as evidence for future reviews.
Keywords: Alveolar bone grafting, Bone substitutes, Bone transplantation, Cleft lip
with or without cleft palate, Medical care |
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