SIGNAL TRANSDUCTION OF CURCUMIN FOR PROTECTION OF ENDOTHELIAL CELL IN HYPERCHOLESTEROLEMIA
"Mechanism of curcumin for protection of endothelial cell was studied in cholesterolfed rabbits. Thirty rabbits were randomly divided into five groups_ The negative control group was fed a standard diet, the positive controi group was fed the same diet with 2 % cholesterol , the curcumin gro...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian |
| Published: |
2009
|
| Subjects: | |
| Online Access: | https://repository.unair.ac.id/135054/1/2.%20Sri%20Agus%20Sudjarwo.pdf https://repository.unair.ac.id/135054/ http://www.lib.unair.ac.id |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universitas Airlangga |
| Language: | Indonesian |
| Summary: | "Mechanism of curcumin for protection of endothelial cell was studied in cholesterolfed
rabbits. Thirty rabbits were randomly divided into five groups_ The negative control
group was fed a standard diet, the positive controi group was fed the same diet with 2
% cholesterol , the curcumin group was fed the same diet with 2 % cholesterol and
curcumin 100 mglKg BW/day, 200 mg/Kg BW/day or 400 mg/Kg BW/day. The
cholesterol-rich diet significantly increased Malondialdehyde (MDA) in the aortic
blood vessels, as reflected by Thiobarbituric Acid-Reactive Substances (TBARS),
inhibited endothelium-dependent vascular relaxations to acetylcholine and decrease
cyciic GMP were compared with vessels from normal rabbits (negative control). In
cholesterol-fed rabbits, curcumin treatment decreased MDA in plasma production,
improved endothelium - dependent relaxations to acetylcholine and increase cyclic
GMP production. These results suggest that dietary treatment of rabbits with
curcumin may prevent superoxide anion (d-) induced inactivation of endotheliumdependent
relaxing factor (EDRF), improve the endothelium-dependent relaxation to
acetylcholine in the aortic blood vessels and increase cyciic GMP content in aortic of
cholesterol-fed rabbits." |
|---|