SIGNAL TRANSDUCTION OF CURCUMIN FOR PROTECTION OF ENDOTHELIAL CELL IN HYPERCHOLESTEROLEMIA

• Main Authors: Sri Agus Sudjarwo, -, Koerniasari, -, Masatoshi Hori, -, Hiroshi Ozaki, -
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian
• Published: 2009
• Subjects: SF600-1100 Veterinary medicine
• Online Access: https://repository.unair.ac.id/135054/1/2.%20Sri%20Agus%20Sudjarwo.pdf; https://repository.unair.ac.id/135054/; http://www.lib.unair.ac.id
• Institution: Universitas Airlangga

"Mechanism of curcumin for protection of endothelial cell was studied in cholesterolfed rabbits. Thirty rabbits were randomly divided into five groups_ The negative control group was fed a standard diet, the positive controi group was fed the same diet with 2 % cholesterol , the curcumin group was fed the same diet with 2 % cholesterol and curcumin 100 mglKg BW/day, 200 mg/Kg BW/day or 400 mg/Kg BW/day. The cholesterol-rich diet significantly increased Malondialdehyde (MDA) in the aortic blood vessels, as reflected by Thiobarbituric Acid-Reactive Substances (TBARS), inhibited endothelium-dependent vascular relaxations to acetylcholine and decrease cyciic GMP were compared with vessels from normal rabbits (negative control). In cholesterol-fed rabbits, curcumin treatment decreased MDA in plasma production, improved endothelium - dependent relaxations to acetylcholine and increase cyclic GMP production. These results suggest that dietary treatment of rabbits with curcumin may prevent superoxide anion (d-) induced inactivation of endotheliumdependent relaxing factor (EDRF), improve the endothelium-dependent relaxation to acetylcholine in the aortic blood vessels and increase cyciic GMP content in aortic of cholesterol-fed rabbits."