Pengaruh tahapan reaksi terhadap persentase hasil sintesis 1,3-Dibenzoilurea
In this research, synthesis 1,3-dibenzoylthiourea was done by using two different ways, which were one step and two steps acylation. The one step acylation was done by reacting thiourea and benzoyl chloride in 1:3 mole equivalency to give 1,3-dibenzoylthiourea...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | English Indonesian |
| Published: |
2005
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/47021/1/050112457.pdf http://repository.unair.ac.id/47021/2/050112457.pdf http://repository.unair.ac.id/47021/ http://ff.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | English Indonesian |
| Summary: | In this research, synthesis 1,3-dibenzoylthiourea was done by using two different ways, which were one step and two steps acylation. The one step
acylation was done by reacting thiourea and benzoyl chloride in 1:3 mole equivalency to give 1,3-dibenzoylthiourea directly, while the two steps acylation was conducted by reacting thiourea with benzoyl chloride to give benzoylthiourea which was re-reacted with be nzoyl chloride to generate 1,3-dibenzoylthiourea.
Purification of compound was done by preparative layer chromatography to give white and odorless crystals.
The identification of the resulted compound was done by TLC test, melting point test, UV-Vis spectrophotometry, FT-IR spectrophotometry and 1 H-NMR spectrometry. Identification showed that the resulted compound was a new compound which was posses –NH group, C=O ester group, and phenyl with para substitution. These methods gave average yield for this compund 12,68 % for the
one step acylation and 4,41% for the two steps acylation.
Keywords : 1,3-dibenzoylthiourea, acylation, thiourea, benzoylthiourea |
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