Pengaruh tahapan reaksi terhadap persentase hasil sintesis 1,3-Dibenzoilurea

• Main Author: Rini Susanti, 050112457
• Format: Theses and Dissertations NonPeerReviewed
• Language: English; Indonesian
• Published: 2005
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/47021/1/050112457.pdf; http://repository.unair.ac.id/47021/2/050112457.pdf; http://repository.unair.ac.id/47021/; http://ff.unair.ac.id
• Institution: Universitas Airlangga

In this research, synthesis 1,3-dibenzoylthiourea was done by using two different ways, which were one step and two steps acylation. The one step acylation was done by reacting thiourea and benzoyl chloride in 1:3 mole equivalency to give 1,3-dibenzoylthiourea directly, while the two steps acylation was conducted by reacting thiourea with benzoyl chloride to give benzoylthiourea which was re-reacted with be nzoyl chloride to generate 1,3-dibenzoylthiourea. Purification of compound was done by preparative layer chromatography to give white and odorless crystals. The identification of the resulted compound was done by TLC test, melting point test, UV-Vis spectrophotometry, FT-IR spectrophotometry and 1 H-NMR spectrometry. Identification showed that the resulted compound was a new compound which was posses –NH group, C=O ester group, and phenyl with para substitution. These methods gave average yield for this compund 12,68 % for the one step acylation and 4,41% for the two steps acylation. Keywords : 1,3-dibenzoylthiourea, acylation, thiourea, benzoylthiourea