TOKSISITAS SUBKRONIS TABLET FRAKSI EA-96 HERBA SAMBILOTO (Andrographis paniculata Nees) PADA HATI DAN GINJAL TIKUS WISTAR
This study aims to determine whether there subchronic toxicity effects, liver and renal histopathology changes, and the effect on levels of SGOT and SGPT mice generated from antimalarial tablet EA-96 fractions bitter herbs (Andrographis paniculata Nees) in mice. The research method checks clinic...
Saved in:
| Main Author: | |
|---|---|
| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian |
| Published: |
2016
|
| Subjects: | |
| Online Access: | http://repository.unair.ac.id/55659/1/FF.FT.%2023-16%20Kur%20t%20abstrak.pdf http://repository.unair.ac.id/55659/19/FF_FT_23-16_Kur_t-min.pdf http://repository.unair.ac.id/55659/ http://lib.unair.ac.id |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian |
| Summary: | This study aims to determine whether there subchronic toxicity
effects, liver and renal histopathology changes, and the effect on
levels of SGOT and SGPT mice generated from antimalarial tablet
EA-96 fractions bitter herbs (Andrographis paniculata Nees) in
mice. The research method checks clinical chemistry, hematology
examination, and macropathology using one-way ANOVA followed
by Post Hoc Test. Histopathology using non-parametric statistical
analysis Kruskal-Wallis. Analysis of clinical chemistry and
hematology, the creatinine and hematocrit resulted in decreased
levels of some of the test group. However, this decline still meets
the normal range of levels. Macropathology careful observation, the
test material influence on relative organ weight percentage of male
and female rat liver in some test groups. Macropathology kidney,
the test material to give effect to the kidney relative organ weight
percentage of female rats to some of the test group.
Histopathological analysis of unknown materials testing EA-96
tablet fraction of Bitter herbs induce histopathological changes in
liver and kidney the mice during the treatment period.
The study concluded that the tablet fraction of Bitter herbs EA-
96 at a dose of 50 mg / kg body weight of mice, 327.6 mg / kg body
weight of mice, and 1000 mg / kg rat and satellite dose 1000 mg / kg
rat toxicity effects subchronic against rats (wistar strain) on
histopathological liver and kidneys for 28 days of treatment. It is
advisable not need to continue subchronic toxicity study for 90 days.
Keywords: Sambiloto, ethyl acetate-96 tablet fraction, clinical
chemistry, histopathology, subchronic toxicit |
|---|