TOKSISITAS SUBKRONIS TABLET FRAKSI EA-96 HERBA SAMBILOTO (Andrographis paniculata Nees) PADA HATI DAN GINJAL TIKUS WISTAR

This study aims to determine whether there subchronic toxicity effects, liver and renal histopathology changes, and the effect on levels of SGOT and SGPT mice generated from antimalarial tablet EA-96 fractions bitter herbs (Andrographis paniculata Nees) in mice. The research method checks clinic...

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Main Author: YESINTA KURNIAWATI, 051211133006
Format: Theses and Dissertations NonPeerReviewed
Language:Indonesian
Indonesian
Published: 2016
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Online Access:http://repository.unair.ac.id/55659/1/FF.FT.%2023-16%20Kur%20t%20abstrak.pdf
http://repository.unair.ac.id/55659/19/FF_FT_23-16_Kur_t-min.pdf
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Institution: Universitas Airlangga
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spelling id-langga.556592018-01-29T21:54:14Z http://repository.unair.ac.id/55659/ TOKSISITAS SUBKRONIS TABLET FRAKSI EA-96 HERBA SAMBILOTO (Andrographis paniculata Nees) PADA HATI DAN GINJAL TIKUS WISTAR YESINTA KURNIAWATI, 051211133006 RC31-1245 Internal medicine RS1-441 Pharmacy and materia medica This study aims to determine whether there subchronic toxicity effects, liver and renal histopathology changes, and the effect on levels of SGOT and SGPT mice generated from antimalarial tablet EA-96 fractions bitter herbs (Andrographis paniculata Nees) in mice. The research method checks clinical chemistry, hematology examination, and macropathology using one-way ANOVA followed by Post Hoc Test. Histopathology using non-parametric statistical analysis Kruskal-Wallis. Analysis of clinical chemistry and hematology, the creatinine and hematocrit resulted in decreased levels of some of the test group. However, this decline still meets the normal range of levels. Macropathology careful observation, the test material influence on relative organ weight percentage of male and female rat liver in some test groups. Macropathology kidney, the test material to give effect to the kidney relative organ weight percentage of female rats to some of the test group. Histopathological analysis of unknown materials testing EA-96 tablet fraction of Bitter herbs induce histopathological changes in liver and kidney the mice during the treatment period. The study concluded that the tablet fraction of Bitter herbs EA- 96 at a dose of 50 mg / kg body weight of mice, 327.6 mg / kg body weight of mice, and 1000 mg / kg rat and satellite dose 1000 mg / kg rat toxicity effects subchronic against rats (wistar strain) on histopathological liver and kidneys for 28 days of treatment. It is advisable not need to continue subchronic toxicity study for 90 days. Keywords: Sambiloto, ethyl acetate-96 tablet fraction, clinical chemistry, histopathology, subchronic toxicit 2016 Thesis NonPeerReviewed text id http://repository.unair.ac.id/55659/1/FF.FT.%2023-16%20Kur%20t%20abstrak.pdf text id http://repository.unair.ac.id/55659/19/FF_FT_23-16_Kur_t-min.pdf YESINTA KURNIAWATI, 051211133006 (2016) TOKSISITAS SUBKRONIS TABLET FRAKSI EA-96 HERBA SAMBILOTO (Andrographis paniculata Nees) PADA HATI DAN GINJAL TIKUS WISTAR. Skripsi thesis, Universitas Airlangga. http://lib.unair.ac.id
institution Universitas Airlangga
building Universitas Airlangga Library
country Indonesia
collection UNAIR Repository
language Indonesian
Indonesian
topic RC31-1245 Internal medicine
RS1-441 Pharmacy and materia medica
spellingShingle RC31-1245 Internal medicine
RS1-441 Pharmacy and materia medica
YESINTA KURNIAWATI, 051211133006
TOKSISITAS SUBKRONIS TABLET FRAKSI EA-96 HERBA SAMBILOTO (Andrographis paniculata Nees) PADA HATI DAN GINJAL TIKUS WISTAR
description This study aims to determine whether there subchronic toxicity effects, liver and renal histopathology changes, and the effect on levels of SGOT and SGPT mice generated from antimalarial tablet EA-96 fractions bitter herbs (Andrographis paniculata Nees) in mice. The research method checks clinical chemistry, hematology examination, and macropathology using one-way ANOVA followed by Post Hoc Test. Histopathology using non-parametric statistical analysis Kruskal-Wallis. Analysis of clinical chemistry and hematology, the creatinine and hematocrit resulted in decreased levels of some of the test group. However, this decline still meets the normal range of levels. Macropathology careful observation, the test material influence on relative organ weight percentage of male and female rat liver in some test groups. Macropathology kidney, the test material to give effect to the kidney relative organ weight percentage of female rats to some of the test group. Histopathological analysis of unknown materials testing EA-96 tablet fraction of Bitter herbs induce histopathological changes in liver and kidney the mice during the treatment period. The study concluded that the tablet fraction of Bitter herbs EA- 96 at a dose of 50 mg / kg body weight of mice, 327.6 mg / kg body weight of mice, and 1000 mg / kg rat and satellite dose 1000 mg / kg rat toxicity effects subchronic against rats (wistar strain) on histopathological liver and kidneys for 28 days of treatment. It is advisable not need to continue subchronic toxicity study for 90 days. Keywords: Sambiloto, ethyl acetate-96 tablet fraction, clinical chemistry, histopathology, subchronic toxicit
format Theses and Dissertations
NonPeerReviewed
author YESINTA KURNIAWATI, 051211133006
author_facet YESINTA KURNIAWATI, 051211133006
author_sort YESINTA KURNIAWATI, 051211133006
title TOKSISITAS SUBKRONIS TABLET FRAKSI EA-96 HERBA SAMBILOTO (Andrographis paniculata Nees) PADA HATI DAN GINJAL TIKUS WISTAR
title_short TOKSISITAS SUBKRONIS TABLET FRAKSI EA-96 HERBA SAMBILOTO (Andrographis paniculata Nees) PADA HATI DAN GINJAL TIKUS WISTAR
title_full TOKSISITAS SUBKRONIS TABLET FRAKSI EA-96 HERBA SAMBILOTO (Andrographis paniculata Nees) PADA HATI DAN GINJAL TIKUS WISTAR
title_fullStr TOKSISITAS SUBKRONIS TABLET FRAKSI EA-96 HERBA SAMBILOTO (Andrographis paniculata Nees) PADA HATI DAN GINJAL TIKUS WISTAR
title_full_unstemmed TOKSISITAS SUBKRONIS TABLET FRAKSI EA-96 HERBA SAMBILOTO (Andrographis paniculata Nees) PADA HATI DAN GINJAL TIKUS WISTAR
title_sort toksisitas subkronis tablet fraksi ea-96 herba sambiloto (andrographis paniculata nees) pada hati dan ginjal tikus wistar
publishDate 2016
url http://repository.unair.ac.id/55659/1/FF.FT.%2023-16%20Kur%20t%20abstrak.pdf
http://repository.unair.ac.id/55659/19/FF_FT_23-16_Kur_t-min.pdf
http://repository.unair.ac.id/55659/
http://lib.unair.ac.id
_version_ 1681147269883101184