SINTESIS SENYAWA ASAM 5-METOKSI-2-(4-METILBENZOILOKSI) BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus)
Synthesis of 5-methoxy-2-(4-methylbenzoyloxy)benzoate Acid And It Anlgesic Activity Test In Mice (Mus musculus) Putri Kusniawati The perpuse of the research is to synthesis novel of derivate salycilic acid 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid and it analgesic activity test in mice. 5-me...
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Format: | Theses and Dissertations NonPeerReviewed |
Language: | Indonesian Indonesian |
Published: |
2016
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Subjects: | |
Online Access: | http://repository.unair.ac.id/56128/1/FF.%20KF.%2015-16%20Kus%20s%20abstrak.pdf http://repository.unair.ac.id/56128/2/FF.%20KF.%2015-16%20Kus%20s.pdf http://repository.unair.ac.id/56128/ http://lib.unair.ac.id |
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Institution: | Universitas Airlangga |
Language: | Indonesian Indonesian |
Summary: | Synthesis of 5-methoxy-2-(4-methylbenzoyloxy)benzoate Acid And It
Anlgesic Activity Test In Mice (Mus musculus)
Putri Kusniawati
The perpuse of the research is to synthesis novel of derivate
salycilic acid 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid and it
analgesic activity test in mice. 5-metoxy-2-(4-methylbenzoyloxy)benzoate
acid synthesized with modification Schotten Baumann method by reacting
5-methoxy salycilic acid and 4-methylbenzoil chloride. Pyridine as catalyst
and THF as solvent. The result obtained 33.65% from synthesis. After that
purity test with 2 method are thin layer chromathography and melting point
test. The structure confirmed by UV spectrophotometry, infrared
spectrophotometry and 1H-NMR spectrometry method. It analgesic activity
tested with writhing test method. And the result are ED50 of 5-methoxy-2-
(4-methylbenzoyloxy)benzoate acid is 22,78 mg/kg body weight and ED50
of acetosal is 80,26 mg/kg body weight. It concluded that 5-methoxy-2-(4-
methylbenzoyloxy)benzoate acid have higher analgesic activity than
acetosal.
Keyword: synthesis, 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid,
analgesic activity, ED50 |
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