SINTESIS SENYAWA ASAM 5-METOKSI-2-(4-METILBENZOILOKSI) BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus)
Synthesis of 5-methoxy-2-(4-methylbenzoyloxy)benzoate Acid And It Anlgesic Activity Test In Mice (Mus musculus) Putri Kusniawati The perpuse of the research is to synthesis novel of derivate salycilic acid 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid and it analgesic activity test in mice. 5-me...
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id-langga.561282017-04-07T00:16:03Z http://repository.unair.ac.id/56128/ SINTESIS SENYAWA ASAM 5-METOKSI-2-(4-METILBENZOILOKSI) BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus) PUTRI KUSNIAWATI, 051211131044 RS1-441 Pharmacy and materia medica Synthesis of 5-methoxy-2-(4-methylbenzoyloxy)benzoate Acid And It Anlgesic Activity Test In Mice (Mus musculus) Putri Kusniawati The perpuse of the research is to synthesis novel of derivate salycilic acid 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid and it analgesic activity test in mice. 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid synthesized with modification Schotten Baumann method by reacting 5-methoxy salycilic acid and 4-methylbenzoil chloride. Pyridine as catalyst and THF as solvent. The result obtained 33.65% from synthesis. After that purity test with 2 method are thin layer chromathography and melting point test. The structure confirmed by UV spectrophotometry, infrared spectrophotometry and 1H-NMR spectrometry method. It analgesic activity tested with writhing test method. And the result are ED50 of 5-methoxy-2- (4-methylbenzoyloxy)benzoate acid is 22,78 mg/kg body weight and ED50 of acetosal is 80,26 mg/kg body weight. It concluded that 5-methoxy-2-(4- methylbenzoyloxy)benzoate acid have higher analgesic activity than acetosal. Keyword: synthesis, 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid, analgesic activity, ED50 2016 Thesis NonPeerReviewed text id http://repository.unair.ac.id/56128/1/FF.%20KF.%2015-16%20Kus%20s%20abstrak.pdf text id http://repository.unair.ac.id/56128/2/FF.%20KF.%2015-16%20Kus%20s.pdf PUTRI KUSNIAWATI, 051211131044 (2016) SINTESIS SENYAWA ASAM 5-METOKSI-2-(4-METILBENZOILOKSI) BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus). Skripsi thesis, Universitas Airlangga. http://lib.unair.ac.id |
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RS1-441 Pharmacy and materia medica PUTRI KUSNIAWATI, 051211131044 SINTESIS SENYAWA ASAM 5-METOKSI-2-(4-METILBENZOILOKSI) BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus) |
description |
Synthesis of 5-methoxy-2-(4-methylbenzoyloxy)benzoate Acid And It
Anlgesic Activity Test In Mice (Mus musculus)
Putri Kusniawati
The perpuse of the research is to synthesis novel of derivate
salycilic acid 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid and it
analgesic activity test in mice. 5-metoxy-2-(4-methylbenzoyloxy)benzoate
acid synthesized with modification Schotten Baumann method by reacting
5-methoxy salycilic acid and 4-methylbenzoil chloride. Pyridine as catalyst
and THF as solvent. The result obtained 33.65% from synthesis. After that
purity test with 2 method are thin layer chromathography and melting point
test. The structure confirmed by UV spectrophotometry, infrared
spectrophotometry and 1H-NMR spectrometry method. It analgesic activity
tested with writhing test method. And the result are ED50 of 5-methoxy-2-
(4-methylbenzoyloxy)benzoate acid is 22,78 mg/kg body weight and ED50
of acetosal is 80,26 mg/kg body weight. It concluded that 5-methoxy-2-(4-
methylbenzoyloxy)benzoate acid have higher analgesic activity than
acetosal.
Keyword: synthesis, 5-metoxy-2-(4-methylbenzoyloxy)benzoate acid,
analgesic activity, ED50 |
format |
Theses and Dissertations NonPeerReviewed |
author |
PUTRI KUSNIAWATI, 051211131044 |
author_facet |
PUTRI KUSNIAWATI, 051211131044 |
author_sort |
PUTRI KUSNIAWATI, 051211131044 |
title |
SINTESIS SENYAWA ASAM 5-METOKSI-2-(4-METILBENZOILOKSI) BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus) |
title_short |
SINTESIS SENYAWA ASAM 5-METOKSI-2-(4-METILBENZOILOKSI) BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus) |
title_full |
SINTESIS SENYAWA ASAM 5-METOKSI-2-(4-METILBENZOILOKSI) BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus) |
title_fullStr |
SINTESIS SENYAWA ASAM 5-METOKSI-2-(4-METILBENZOILOKSI) BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus) |
title_full_unstemmed |
SINTESIS SENYAWA ASAM 5-METOKSI-2-(4-METILBENZOILOKSI) BENZOAT DAN UJI AKTIVITAS ANALGESIKNYA PADA MENCIT (Mus musculus) |
title_sort |
sintesis senyawa asam 5-metoksi-2-(4-metilbenzoiloksi) benzoat dan uji aktivitas analgesiknya pada mencit (mus musculus) |
publishDate |
2016 |
url |
http://repository.unair.ac.id/56128/1/FF.%20KF.%2015-16%20Kus%20s%20abstrak.pdf http://repository.unair.ac.id/56128/2/FF.%20KF.%2015-16%20Kus%20s.pdf http://repository.unair.ac.id/56128/ http://lib.unair.ac.id |
_version_ |
1681147350391717888 |