Dissolution Enhancemnet of Curcumin by Hydroxypropy-β-Cyclodextrin Complexation
The purpose of this study describes the formation of inclusion complex by coevaporation of curcumin using hydroxypropyl-β- cyclodextrin as carriers, to improve the solubility and dissolution of drug. Methods: The preparation of inclusion complex was carried out by using solvent method. The drug a...
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| Main Authors: | , , |
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| Format: | Article PeerReviewed |
| Language: | English Indonesian |
| Published: |
Innovare Academic Sciences
2013
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/56530/1/7346.pdf http://repository.unair.ac.id/56530/2/2%20Penilaian%20Reviwear.pdf http://repository.unair.ac.id/56530/ https://www.ijppsjournal.com/Vol5Suppl3.htm |
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| Institution: | Universitas Airlangga |
| Language: | English Indonesian |
| Summary: | The purpose of this study describes the formation of inclusion complex by coevaporation of curcumin using hydroxypropyl-β-
cyclodextrin as carriers, to improve the solubility and dissolution of drug.
Methods: The preparation of inclusion complex was carried out by using solvent method. The drug and carrier were dissolved in alcohol and
subjected to solvent evaporation by a rotary evaporator. The residual powder preparation was allowed to dry overnight in vacuum desiccator,
pulverized and sieved through # 60 mesh. The invitro dissolution testing was performed media in HCl 0.1 N aqueous solution. Characterization of
inclusion complex and physical mixture was further evaluation using differential thermal analysis (DTA), powder X-ray diffraction (PXRD), FTIR
spectrophotometry and a scanning electron microscope (SEM).
The results: Evaluation of the phase solubility studies revealed a AL type diagram with complexation of equimolar ratio and solubility constant of
30.09 mM
-1
. In-vitro dissolution studies showed that the curcumin entrapped in coevaporated complexes dissolved much faster than the
incomplexed dissolved drug and physical mixtures. X-ray diffraction indicated loss a crystalline nature of the drug, FTIR, DTA studies revealed no
interaction between curcumin and HPβCD.
Conclusions: Inclusion complex of curcumin with HPβCD appears to have the advantage of dissolution enhancement and that may lead to improved
bioavailability. |
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