Dissolution Enhancemnet of Curcumin by Hydroxypropy-β-Cyclodextrin Complexation

• Main Authors: ACHMAD, FUAD HAFID, ACHMAD, RADJARAM, DWI, SETYAWAN
• Format: Article PeerReviewed
• Language: English; Indonesian
• Published: Innovare Academic Sciences 2013
• Subjects: R Medicine; RS Pharmacy and materia medica; RS1-441 Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/56530/1/7346.pdf; http://repository.unair.ac.id/56530/2/2%20Penilaian%20Reviwear.pdf; http://repository.unair.ac.id/56530/; https://www.ijppsjournal.com/Vol5Suppl3.htm
• Institution: Universitas Airlangga

The purpose of this study describes the formation of inclusion complex by coevaporation of curcumin using hydroxypropyl-β- cyclodextrin as carriers, to improve the solubility and dissolution of drug. Methods: The preparation of inclusion complex was carried out by using solvent method. The drug and carrier were dissolved in alcohol and subjected to solvent evaporation by a rotary evaporator. The residual powder preparation was allowed to dry overnight in vacuum desiccator, pulverized and sieved through # 60 mesh. The invitro dissolution testing was performed media in HCl 0.1 N aqueous solution. Characterization of inclusion complex and physical mixture was further evaluation using differential thermal analysis (DTA), powder X-ray diffraction (PXRD), FTIR spectrophotometry and a scanning electron microscope (SEM). The results: Evaluation of the phase solubility studies revealed a AL type diagram with complexation of equimolar ratio and solubility constant of 30.09 mM -1 . In-vitro dissolution studies showed that the curcumin entrapped in coevaporated complexes dissolved much faster than the incomplexed dissolved drug and physical mixtures. X-ray diffraction indicated loss a crystalline nature of the drug, FTIR, DTA studies revealed no interaction between curcumin and HPβCD. Conclusions: Inclusion complex of curcumin with HPβCD appears to have the advantage of dissolution enhancement and that may lead to improved bioavailability.