EFFECT OF Polygonum minus LEAVES EXTRACT ON HISTOPATHOLOGICAL FEATURES OF MICE (Mus musculus) LIVER INDUCED BY MERCURIC CHLORIDE
The aim of this study was to examined the protective effect of Polygonum minus leaf extract on histopathological changes of the liver induced by mercuric chloride in mice (Mus musculus). Thirty male mice were divided into five groups, six mice each and administered through oral gavage with differ...
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | English English |
| Published: |
2017
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/60889/1/ABSTRACT%20KKC%20KK%20KH.%20159.17%20Ans%20e.pdf http://repository.unair.ac.id/60889/2/FULLTEXT%20KKC%20KK%20KH.%20159.17%20Ans%20e.pdf http://repository.unair.ac.id/60889/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | English English |
| Summary: | The aim of this study was to examined the protective effect of Polygonum
minus leaf extract on histopathological changes of the liver induced by mercuric
chloride in mice (Mus musculus). Thirty male mice were divided into five groups,
six mice each and administered through oral gavage with different treatments for
21 days. The treatments were C– (CMC Na 0.5% solution + aquadest), C+ (CMC
Na 0.5% solution + 8 mg/kg bw mercuric chloride), T1, T2, and T3 (200, 400, and
800 mg/kg bw Polygonum minus leaf extract respectively + 8 mg/kg bw mercuric
chloride). After treatments, histopathological evaluation was done to calculate the
percentage of the lesion using Arsad scoring method. The data was analyzed by
Kruskal Wallis and Mann-Whitney Test. The research showed significant
different (p < 0.05) among the treatment groups. The conclusion of this research is
Polygonum minus leaf extract can protect mice liver from destructive effect of
mercuric chloride, and the best dose was 400 mg/kg bw. |
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