HUBUNGAN ANTARA EKSPRESI IL-10 DENGAN TIPE HISTOPATOLOGI PADA PENDERITA KARSINOMA NASOFARING
Nasopharyngeal carcinoma (NPC) is a malignancy derived from lymphoepithelial tissue and nasopharyngeal epithelial cells. Response therapy of NPC can be evaluated from hisopathological type, but in some patients with same histopathological type illustrated a different response therapy. IL-10 expre...
Saved in:
| Main Author: | |
|---|---|
| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | English English |
| Published: |
2017
|
| Subjects: | |
| Online Access: | http://repository.unair.ac.id/64858/1/abstrak.pdf http://repository.unair.ac.id/64858/2/karya%20akhir%20dr.%20hamita.pdf http://repository.unair.ac.id/64858/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universitas Airlangga |
| Language: | English English |
| Summary: | Nasopharyngeal carcinoma (NPC) is a malignancy derived from
lymphoepithelial tissue and nasopharyngeal epithelial cells. Response therapy of
NPC can be evaluated from hisopathological type, but in some patients with same
histopathological type illustrated a different response therapy. IL-10 expression
expected to predict the better response therapy of NPC. IL-10 expression by
immunohistochemical examination associated with the differentiation of tumors.
Purpose: To find out the association between IL-10 expression and
histopathological type in NPC patients. Methods: the study was analitic
observational with cross sectional approach. Samples were collected by
consecutive sampling. Formalin-fixed paraffin-embedded biopsy specimens were
obtained. The expression of IL-10 was studied with immunohistochemistry using
rabbit polyclonal antibody Anti IL-10 ab34843 (Abcam®, Cambridge - UK).
Assessment of the staining was performed by pathologist independent used Allred
scale. The Fisher’s exact test was used to determine the correlation expression of
IL-10 and histopathological type of nasopharyngeal carcinoma. Statistical
significance was defined as p < 0.05. Result: The result of IL-10 expression in
NPC patients with histopathological type I WHO NPC obtained 1 sample was
strong positive expression and 2 sample was weak positive expression. In patients
with histopathological type II WHO NPC obtained 2 samples was strong positive
expression and 12 samples was weak positive expression. In patients with
histopathological type III WHO NPC obtained 9 samples was strong expression
and 7 samples was weak positive expression. From all sample there was 36.36 %
was strong positive expression and 63.64% was weak positive expression. There
were increase of amount cells that give strong expression on WHO type III.
Statistical analysis using Fisher’s exact test was obtained p = 0.040 with a
contingency coefficient 0.384. Conclusion: There was moderate association
between IL-10 expression and histopathological type in NPC patients. |
|---|