HUBUNGAN ANTARA EKSPRESI IL-10 DENGAN TIPE HISTOPATOLOGI PADA PENDERITA KARSINOMA NASOFARING
Nasopharyngeal carcinoma (NPC) is a malignancy derived from lymphoepithelial tissue and nasopharyngeal epithelial cells. Response therapy of NPC can be evaluated from hisopathological type, but in some patients with same histopathological type illustrated a different response therapy. IL-10 expre...
Saved in:
Main Author: | |
---|---|
Format: | Theses and Dissertations NonPeerReviewed |
Language: | English English |
Published: |
2017
|
Subjects: | |
Online Access: | http://repository.unair.ac.id/64858/1/abstrak.pdf http://repository.unair.ac.id/64858/2/karya%20akhir%20dr.%20hamita.pdf http://repository.unair.ac.id/64858/ |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universitas Airlangga |
Language: | English English |
id |
id-langga.64858 |
---|---|
record_format |
dspace |
spelling |
id-langga.648582017-10-25T19:10:04Z http://repository.unair.ac.id/64858/ HUBUNGAN ANTARA EKSPRESI IL-10 DENGAN TIPE HISTOPATOLOGI PADA PENDERITA KARSINOMA NASOFARING Hamita, NIM011228056306 R Medicine Nasopharyngeal carcinoma (NPC) is a malignancy derived from lymphoepithelial tissue and nasopharyngeal epithelial cells. Response therapy of NPC can be evaluated from hisopathological type, but in some patients with same histopathological type illustrated a different response therapy. IL-10 expression expected to predict the better response therapy of NPC. IL-10 expression by immunohistochemical examination associated with the differentiation of tumors. Purpose: To find out the association between IL-10 expression and histopathological type in NPC patients. Methods: the study was analitic observational with cross sectional approach. Samples were collected by consecutive sampling. Formalin-fixed paraffin-embedded biopsy specimens were obtained. The expression of IL-10 was studied with immunohistochemistry using rabbit polyclonal antibody Anti IL-10 ab34843 (Abcam®, Cambridge - UK). Assessment of the staining was performed by pathologist independent used Allred scale. The Fisher’s exact test was used to determine the correlation expression of IL-10 and histopathological type of nasopharyngeal carcinoma. Statistical significance was defined as p < 0.05. Result: The result of IL-10 expression in NPC patients with histopathological type I WHO NPC obtained 1 sample was strong positive expression and 2 sample was weak positive expression. In patients with histopathological type II WHO NPC obtained 2 samples was strong positive expression and 12 samples was weak positive expression. In patients with histopathological type III WHO NPC obtained 9 samples was strong expression and 7 samples was weak positive expression. From all sample there was 36.36 % was strong positive expression and 63.64% was weak positive expression. There were increase of amount cells that give strong expression on WHO type III. Statistical analysis using Fisher’s exact test was obtained p = 0.040 with a contingency coefficient 0.384. Conclusion: There was moderate association between IL-10 expression and histopathological type in NPC patients. 2017-10-26 Thesis NonPeerReviewed text en http://repository.unair.ac.id/64858/1/abstrak.pdf text en http://repository.unair.ac.id/64858/2/karya%20akhir%20dr.%20hamita.pdf Hamita, NIM011228056306 (2017) HUBUNGAN ANTARA EKSPRESI IL-10 DENGAN TIPE HISTOPATOLOGI PADA PENDERITA KARSINOMA NASOFARING. Thesis thesis, Universitas Airlangga. |
institution |
Universitas Airlangga |
building |
Universitas Airlangga Library |
country |
Indonesia |
collection |
UNAIR Repository |
language |
English English |
topic |
R Medicine |
spellingShingle |
R Medicine Hamita, NIM011228056306 HUBUNGAN ANTARA EKSPRESI IL-10 DENGAN TIPE HISTOPATOLOGI PADA PENDERITA KARSINOMA NASOFARING |
description |
Nasopharyngeal carcinoma (NPC) is a malignancy derived from
lymphoepithelial tissue and nasopharyngeal epithelial cells. Response therapy of
NPC can be evaluated from hisopathological type, but in some patients with same
histopathological type illustrated a different response therapy. IL-10 expression
expected to predict the better response therapy of NPC. IL-10 expression by
immunohistochemical examination associated with the differentiation of tumors.
Purpose: To find out the association between IL-10 expression and
histopathological type in NPC patients. Methods: the study was analitic
observational with cross sectional approach. Samples were collected by
consecutive sampling. Formalin-fixed paraffin-embedded biopsy specimens were
obtained. The expression of IL-10 was studied with immunohistochemistry using
rabbit polyclonal antibody Anti IL-10 ab34843 (Abcam®, Cambridge - UK).
Assessment of the staining was performed by pathologist independent used Allred
scale. The Fisher’s exact test was used to determine the correlation expression of
IL-10 and histopathological type of nasopharyngeal carcinoma. Statistical
significance was defined as p < 0.05. Result: The result of IL-10 expression in
NPC patients with histopathological type I WHO NPC obtained 1 sample was
strong positive expression and 2 sample was weak positive expression. In patients
with histopathological type II WHO NPC obtained 2 samples was strong positive
expression and 12 samples was weak positive expression. In patients with
histopathological type III WHO NPC obtained 9 samples was strong expression
and 7 samples was weak positive expression. From all sample there was 36.36 %
was strong positive expression and 63.64% was weak positive expression. There
were increase of amount cells that give strong expression on WHO type III.
Statistical analysis using Fisher’s exact test was obtained p = 0.040 with a
contingency coefficient 0.384. Conclusion: There was moderate association
between IL-10 expression and histopathological type in NPC patients. |
format |
Theses and Dissertations NonPeerReviewed |
author |
Hamita, NIM011228056306 |
author_facet |
Hamita, NIM011228056306 |
author_sort |
Hamita, NIM011228056306 |
title |
HUBUNGAN ANTARA EKSPRESI IL-10
DENGAN TIPE HISTOPATOLOGI
PADA PENDERITA KARSINOMA NASOFARING |
title_short |
HUBUNGAN ANTARA EKSPRESI IL-10
DENGAN TIPE HISTOPATOLOGI
PADA PENDERITA KARSINOMA NASOFARING |
title_full |
HUBUNGAN ANTARA EKSPRESI IL-10
DENGAN TIPE HISTOPATOLOGI
PADA PENDERITA KARSINOMA NASOFARING |
title_fullStr |
HUBUNGAN ANTARA EKSPRESI IL-10
DENGAN TIPE HISTOPATOLOGI
PADA PENDERITA KARSINOMA NASOFARING |
title_full_unstemmed |
HUBUNGAN ANTARA EKSPRESI IL-10
DENGAN TIPE HISTOPATOLOGI
PADA PENDERITA KARSINOMA NASOFARING |
title_sort |
hubungan antara ekspresi il-10
dengan tipe histopatologi
pada penderita karsinoma nasofaring |
publishDate |
2017 |
url |
http://repository.unair.ac.id/64858/1/abstrak.pdf http://repository.unair.ac.id/64858/2/karya%20akhir%20dr.%20hamita.pdf http://repository.unair.ac.id/64858/ |
_version_ |
1681148832065257472 |