UJI AKTIVITAS ANTITUSIF EKSTRAK DAN SIRUP EKSTRAK ETANOL HERBA Mentha arvensis L.
This study aims to determine the effect of ethanol extract and ethanol extract syrup of Mentha arvensis L. herb on cough’s frequency in mice. Mice of either sex (BALB/c) weighing between 25-35 g were randomly assigened to seven groups (n = 5), ie positive control (30 mg/kg codein phosphate), neg...
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Format: | Theses and Dissertations NonPeerReviewed |
Language: | Indonesian Indonesian |
Published: |
2017
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Subjects: | |
Online Access: | http://repository.unair.ac.id/65091/1/FF.FT.05.17%20.%20Rak.u%20-%20ABSTRAK.pdf http://repository.unair.ac.id/65091/2/FF.FT.05.17%20.%20Rak.u%20-%20SEC.pdf http://repository.unair.ac.id/65091/ http://lib.unair.ac.id |
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Institution: | Universitas Airlangga |
Language: | Indonesian Indonesian |
Summary: | This study aims to determine the effect of ethanol extract and ethanol
extract syrup of Mentha arvensis L. herb on cough’s frequency in mice. Mice
of either sex (BALB/c) weighing between 25-35 g were randomly assigened
to seven groups (n = 5), ie positive control (30 mg/kg codein phosphate),
negative control extract (0.5% CMC-Na), treatment group 1, 2, 3 (200, 400
and 600 mg/kg ethanol extract), negative control syrup (mixed of 15%
propylenglycol, 67% sucrose, and aquadest), and treatment group 4 (600
mg/kg ethanol extract syrup). Each test preparation was administered orally
0.2 mL/kg. After 60 minutes administration, the animal was put into a 1000
mL chamber and exposed to 0.3 mL of 25% ammonium hydroxide solution
for 45 seconds. Furthermore, without removing the experimental animals
from within the chamber, then the frequency of cough for 5 minutes were
observed.
The results showed that ethanol extract of M. arvensis herb has
antitussive activity by decreasing frequency of cough in a dose dependent
manner with significant figure value of p < 0.05. Ethanol extract of M.
arvensis herb at doses of 200, 400 and 600 mg/kg gave cough suppression of
25.2%; 34.2%; and 47.4%, respectively. The syrup of M. arvensis herb
ethanol extract was made at the same dose as the extract dose which has the
greatest decrease of cough frequency (600 mg/kg) which then gives cough
suppression of 46.2%. |
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