UJI AKTIVITAS ANTITUSIF EKSTRAK DAN SIRUP EKSTRAK ETANOL HERBA Mentha arvensis L.

• Main Author: RATIH RAKASIWI, 051311133014
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian
• Published: 2017
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/65091/1/FF.FT.05.17%20.%20Rak.u%20-%20ABSTRAK.pdf; http://repository.unair.ac.id/65091/2/FF.FT.05.17%20.%20Rak.u%20-%20SEC.pdf; http://repository.unair.ac.id/65091/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

This study aims to determine the effect of ethanol extract and ethanol extract syrup of Mentha arvensis L. herb on cough’s frequency in mice. Mice of either sex (BALB/c) weighing between 25-35 g were randomly assigened to seven groups (n = 5), ie positive control (30 mg/kg codein phosphate), negative control extract (0.5% CMC-Na), treatment group 1, 2, 3 (200, 400 and 600 mg/kg ethanol extract), negative control syrup (mixed of 15% propylenglycol, 67% sucrose, and aquadest), and treatment group 4 (600 mg/kg ethanol extract syrup). Each test preparation was administered orally 0.2 mL/kg. After 60 minutes administration, the animal was put into a 1000 mL chamber and exposed to 0.3 mL of 25% ammonium hydroxide solution for 45 seconds. Furthermore, without removing the experimental animals from within the chamber, then the frequency of cough for 5 minutes were observed. The results showed that ethanol extract of M. arvensis herb has antitussive activity by decreasing frequency of cough in a dose dependent manner with significant figure value of p < 0.05. Ethanol extract of M. arvensis herb at doses of 200, 400 and 600 mg/kg gave cough suppression of 25.2%; 34.2%; and 47.4%, respectively. The syrup of M. arvensis herb ethanol extract was made at the same dose as the extract dose which has the greatest decrease of cough frequency (600 mg/kg) which then gives cough suppression of 46.2%.