UJI AKTIVITAS ANTITUSIF DAN UJI STABILITAS FISIK SIRUP EKSTRAK ETANOL BUAH BELIMBING WULUH (Averrhoa bilimbi L.)
The aim of this study was to evaluate the antitussive activity and physical stability of the ethanolic extract syrup of Bilimbi (Averrhoa bilimbi L.) fruit. The antitussive activity was studied using 25 ammonium hydroxide induced male mice (BALB/c strain) which were divided into 5 groups. Group...
Saved in:
| Main Author: | |
|---|---|
| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian English |
| Published: |
2017
|
| Subjects: | |
| Online Access: | http://repository.unair.ac.id/65092/1/FF.FT.06.17%20.%20Erm.u%20-%20ABSTRAK.pdf http://repository.unair.ac.id/65092/2/FF.FT.06.17%20.%20Erm.u%20-%20SEC.pdf http://repository.unair.ac.id/65092/ http://lib.unair.ac.id |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universitas Airlangga |
| Language: | Indonesian English |
| Summary: | The aim of this study was to evaluate the antitussive activity and
physical stability of the ethanolic extract syrup of Bilimbi (Averrhoa bilimbi
L.) fruit. The antitussive activity was studied using 25 ammonium
hydroxide induced male mice (BALB/c strain) which were divided into 5
groups. Group I and group II were subsequently administered with
0.2ml/kgBW of Codein Phosphate (30mg/kg) as positive control, and
solution mixture of propyleneglycol, sucrose, and aquadest as negative
control, group III, IV, and V were administered with 0.32ml/kgBW of
ethanolic extract syrup orally, 60 minutes prior to placed into 1000 ml of
chamber and exposed with 0.3 ml of 25% ammonium hydroxide solution
for 45 seconds. The cough frequency was observed and measured for 5
minutes without removing the mice from the chamber. The result of
antitussive test showed that the ethanolic exract syrup of Bilimbi fruit
significantly inhibited the frequency of cough (p<0.05) as the doses were
increased. Ethanolic extract syrup of Bilimbi fruit at doses 10%, 15%, and
20% showed percentage of cough inhibition 24.13%; 39.36%; 39.36%
respectively after 60 minutes of drug administration. The physical stability
was evaluated by the physicochemical parameters such as physical
appearance, pH, density, and homogenity during 0 hr, 24 hr, 48 hr, and 72
hr at the temperature of 5ºC, 28ºC, and 47ºC. The result of physical stability
test showed that there were no changes of the physicochemical parameters
during 0 hr, 24 hr, 48 hr, and 72 hr at the temperature of 5ºC, 28ºC, and
47ºC. In conclution this study provided pharmacological evidence in
supporting of empirical used of the stable ethanolic extract syrup of Bilimbi
(Averrhoa bilimbi L.) fruit as an antitussive. |
|---|