UJI AKTIVITAS ANTITUSIF DAN UJI STABILITAS FISIK SIRUP EKSTRAK ETANOL BUAH BELIMBING WULUH (Averrhoa bilimbi L.)

• Main Author: WAHYU ERMAWATI, 051311133002
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; English
• Published: 2017
• Subjects: RS Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/65092/1/FF.FT.06.17%20.%20Erm.u%20-%20ABSTRAK.pdf; http://repository.unair.ac.id/65092/2/FF.FT.06.17%20.%20Erm.u%20-%20SEC.pdf; http://repository.unair.ac.id/65092/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

The aim of this study was to evaluate the antitussive activity and physical stability of the ethanolic extract syrup of Bilimbi (Averrhoa bilimbi L.) fruit. The antitussive activity was studied using 25 ammonium hydroxide induced male mice (BALB/c strain) which were divided into 5 groups. Group I and group II were subsequently administered with 0.2ml/kgBW of Codein Phosphate (30mg/kg) as positive control, and solution mixture of propyleneglycol, sucrose, and aquadest as negative control, group III, IV, and V were administered with 0.32ml/kgBW of ethanolic extract syrup orally, 60 minutes prior to placed into 1000 ml of chamber and exposed with 0.3 ml of 25% ammonium hydroxide solution for 45 seconds. The cough frequency was observed and measured for 5 minutes without removing the mice from the chamber. The result of antitussive test showed that the ethanolic exract syrup of Bilimbi fruit significantly inhibited the frequency of cough (p<0.05) as the doses were increased. Ethanolic extract syrup of Bilimbi fruit at doses 10%, 15%, and 20% showed percentage of cough inhibition 24.13%; 39.36%; 39.36% respectively after 60 minutes of drug administration. The physical stability was evaluated by the physicochemical parameters such as physical appearance, pH, density, and homogenity during 0 hr, 24 hr, 48 hr, and 72 hr at the temperature of 5ºC, 28ºC, and 47ºC. The result of physical stability test showed that there were no changes of the physicochemical parameters during 0 hr, 24 hr, 48 hr, and 72 hr at the temperature of 5ºC, 28ºC, and 47ºC. In conclution this study provided pharmacological evidence in supporting of empirical used of the stable ethanolic extract syrup of Bilimbi (Averrhoa bilimbi L.) fruit as an antitussive.