PENENTUAN KADAR KOLESTEROL PADA PEMBERIAN SERBUK PORANG (Amorphophallus onchophyllus) DAN SERBUK KONJAK(Amorphophallus konjac) TERSTANDAR GLUKOMANAN PADA MENCIT PUTIH (Mus Musculus)
The major component of porang and konjac powder from porang tuber (Amorphophallus oncophyllus) and konjac powder (Amorphophallus konjac) was glucomannan. Glucomannan can reduce cholesterol level by forming gel and expanding in the stomach, thus results in the slow lipid absorption and reduce ch...
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Format: | Theses and Dissertations NonPeerReviewed |
Language: | Indonesian Indonesian |
Published: |
2017
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Subjects: | |
Online Access: | http://repository.unair.ac.id/65262/1/FF.KF.29.17%20.%20Cah.p%20-%20ABSTRAK.pdf http://repository.unair.ac.id/65262/2/FF.KF.29.17%20.%20Cah.p%20-%20SEC.pdf http://repository.unair.ac.id/65262/ http://lib.unair.ac.id |
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Institution: | Universitas Airlangga |
Language: | Indonesian Indonesian |
Summary: | The major component of porang and konjac powder
from porang tuber (Amorphophallus oncophyllus) and konjac
powder (Amorphophallus konjac) was glucomannan.
Glucomannan can reduce cholesterol level by forming gel and
expanding in the stomach, thus results in the slow lipid absorption
and reduce cholesterol levels. Porang and konjac powder that had
been standardized with its level of glucomannan was used as
sample. The level of glucomannan obtained porang powder was
53,33±0,74 (%,b/b) while glucomannan level of konjac powder
was 61,24±0,61 (%,b/b).This study consisted of 8 treatment
groups contained male mice aged 2-3 months. Those mice were
induced with mixture of high-cholesterol diet (lard: duck egg
yolk) and PTU 0,1% and the cholesterol level was checked 3 days
after the induction (pretest) and continue to be checked up to 21
days. Treatment groups consisted of negative control (CMC Na
0,3%), positive control (Simvastatin), treatment group I, II, III,
IV, V, VI with the administration of porang powder standard
glukomannan dose of 85; 165; 250 mg/ kg body weight of mice
and konjak powder standard glukomannan dose of 85; 165; 250
mg/ kg Body weight of mice.The treatment was administered up
to 21 days with cholesterol checking in day 7, 10, 14 and 21. The
results were analyzed with oneway ANOVA (significant value of
5%). The analyzed results indicated that glucomannan
standardized konjac powder with dose of 250 mg/kg body weight
can reduce cholesterol levels in mice significantly after 7 days of
administration (sig<0,05). |
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