PENGARUH KADAR DIETILFTALAT SEBAGAI PLASTICIZER TERHADAP VIABILITAS DAN DAYA PROTEKSI MIKROPARTIKEL Lactobacillus casei FNCC 0090 PADA KONDISI ASAM (Menggunakan Matriks Kopolimer Asam Metakrilat Tipe L)

• Main Author: DWI NURUL ARISKA, 051411131126
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian
• Published: 2018
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: http://repository.unair.ac.id/77203/1/FF.F.%2011-18%20Ari%20p%20Abstrak.pdf; http://repository.unair.ac.id/77203/2/FF.F.%2011-18%20Ari%20p.pdf; http://repository.unair.ac.id/77203/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

Microparticle was an efficient system to protect probiotic from extreme condition in gastric and release them in intestine. The most used probiotic is Lactobacillus casei. Microparticle Lactobacillus casei was made by spray drying. There were four formulas such as formula I, formula II, formula III and formula IV. Every formulas contain methacrylic acid copolymer L type 1% and different concentration of diethylphthalate. Formula I contain diethylphthalate 0%, formula II with diethylphthalate 10%, formula III with diethylphthalate 20%, and formula IV contain diethylphthalate 30%. Viability and protection microparticle from acidic condition were performed to all formulas. The result showed that the highest viability Lactobacillus casei after encapsulation was obtained by formula II with no significant difference between each formulas. The result of protection microparticle Lactobacillus casei from acidic condition test showed that increasing diethylphthalate concentration decrease protection microparticle form acidic condition with no significant difference between each formulas.