PENGARUH PAPARAN UAP ROKOK ELEKTRIK TERHADAP GAMBARAN HISTOPATOLOGI ORGAN PULMO TIKUS PUTIH GALUR SPRAGUE DAWLEY

• Main Author: CAROLINA ARDY MEGA PERTIWI, 061511535023
• Format: Theses and Dissertations NonPeerReviewed
• Language: Indonesian; Indonesian; Indonesian; Indonesian
• Published: 2019
• Subjects: QL750-795 Animal behavior; TS1950-1982 Animal products
• Online Access: http://repository.unair.ac.id/84094/1/PSDKU.%20KH%2017%20-%2019%20Per%20P%20-%20ABSTRAK.pdf; http://repository.unair.ac.id/84094/2/PSDKU.%20KH%2017%20-%2019%20Per%20P%20-%20DAFTAR%20ISI.pdf; http://repository.unair.ac.id/84094/3/PSDKU.%20KH%2017%20-%2019%20Per%20P%20-%20DAFTAR%20PUSTAKA.pdf; http://repository.unair.ac.id/84094/4/PSDKU.%20KH%2017%20-%2019%20Per%20P%20-%20FULLTEXT.pdf; http://repository.unair.ac.id/84094/; http://lib.unair.ac.id
• Institution: Universitas Airlangga

Electric cigarettes (e-cigarettes) contain nicotine which cause of lung obstruction. The nicotine exposure in e-cigarette can increase the accumulation off inflammatory cells in pulmo. Nicotine which play role as a free radicals, especially within respiratory system. This study was aimed to identify the histopathology appearance of rat’s pulmo against exposure to e-cigarette. A total of 20 rats which divided in 5 groups, control group (K) were not exposed by e-cigarette and treatment group were exposed by e-cigarette in different doses, P1 (0,3mg/ml), P2 (3mg/ml), P3 (12 mg/ml), P4 (36 mg/ml) respectively. After 14 days of treatment, rats were euthanasia and necropsy method was performed to identify macroscopy change, also the pulmo organs were dissected and preserved for histopathological study using Hematoxilin-Eosin staining. The results, show that damage of pulmo was defected within histopathology examination using 400x magnification. Moreover, the data was analyzed using Kruskal-Wallis test and continued by Mann Whitney Test which show a significant different (P < 0,05). Average result from pulmo organs of Rats Sprague dawley is Control (K) = 3,00; Treatment 1 (P1) (0.3 mg/ml) = 6,00; P2 (3mg/ml) = 12,00 ;P3(12mg/ml) = 13,00 and P4(36mg/ml) = 18,50 and nicotine dose of minimum is 3 mg/ml . In conclude, the exposure of ecigarette have significant damage effect of pulmo organs in rats.