Mekanisme Molekuler Antidiabetika Vanadil Sulfat

Previous study showed that vanadyl sulphate can effectively lowered blood glucose level in streptozotosin-induce diabetic mice. This study is aimed to reveal the molecular mechanism of vanadyl sulphate in lowering blood glucose level. Diabetic mice were given vanadyl sulphate suspension in CMC-Na on...

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Main Authors: Junaidi Khotib, NIDN. 0022107001, Debra Dorotea, Elisabet Kasih, Nur Palestin, Pharmasinta Putri H., Imam Susilo
Format: Article PeerReviewed
Language:English
English
Published: Universitas Airlangga 2011
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Online Access:http://repository.unair.ac.id/85392/1/C32.pdf
http://repository.unair.ac.id/85392/2/Validasi%20C-32.pdf
http://repository.unair.ac.id/85392/
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Institution: Universitas Airlangga
Language: English
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spelling id-langga.853922019-08-14T08:35:00Z http://repository.unair.ac.id/85392/ Mekanisme Molekuler Antidiabetika Vanadil Sulfat Junaidi Khotib, NIDN. 0022107001 Debra Dorotea Elisabet Kasih Nur Palestin Pharmasinta Putri H. Imam Susilo R Medicine RS Pharmacy and materia medica Previous study showed that vanadyl sulphate can effectively lowered blood glucose level in streptozotosin-induce diabetic mice. This study is aimed to reveal the molecular mechanism of vanadyl sulphate in lowering blood glucose level. Diabetic mice were given vanadyl sulphate suspension in CMC-Na once a day for 7 days with the following dosage, 3, 30, 100 mg/kg body weight. On day 28, mice were sacrifice and the muscle, liver, adipose tissue and pancreas were taken. Histochemistry staining with haematoxyllin-eosin and fuchsin aldehyde \>>as conducted to observe changes in sellular structure.Changes in molecular level were observed by immunohystochemistry-approach with insulin, glucose transporter-4 telomerase and apoptosis antibody receptors. Results showed that vanadyl sulphate can imporove the morphology of muscle, liver, adipose and /3-pancreas cells that were damaged in streptozotocin induced diabetes. Muscle cells showed significant increase in diameter and glicogen sorage also increased. Fatty cells in the liver also decrease and damage of fatty cells also decrease. These improvement were in correlation with the increase in the activity of insulin receptor and glucose transporter-4 caused by vanadyl sulphate medication Universitas Airlangga 2011 Article PeerReviewed text en http://repository.unair.ac.id/85392/1/C32.pdf text en http://repository.unair.ac.id/85392/2/Validasi%20C-32.pdf Junaidi Khotib, NIDN. 0022107001 and Debra Dorotea and Elisabet Kasih and Nur Palestin and Pharmasinta Putri H. and Imam Susilo (2011) Mekanisme Molekuler Antidiabetika Vanadil Sulfat. Majalah Farmasi Airlangga, 9 (1). pp. 16-21. ISSN 0852-1050
institution Universitas Airlangga
building Universitas Airlangga Library
country Indonesia
collection UNAIR Repository
language English
English
topic R Medicine
RS Pharmacy and materia medica
spellingShingle R Medicine
RS Pharmacy and materia medica
Junaidi Khotib, NIDN. 0022107001
Debra Dorotea
Elisabet Kasih
Nur Palestin
Pharmasinta Putri H.
Imam Susilo
Mekanisme Molekuler Antidiabetika Vanadil Sulfat
description Previous study showed that vanadyl sulphate can effectively lowered blood glucose level in streptozotosin-induce diabetic mice. This study is aimed to reveal the molecular mechanism of vanadyl sulphate in lowering blood glucose level. Diabetic mice were given vanadyl sulphate suspension in CMC-Na once a day for 7 days with the following dosage, 3, 30, 100 mg/kg body weight. On day 28, mice were sacrifice and the muscle, liver, adipose tissue and pancreas were taken. Histochemistry staining with haematoxyllin-eosin and fuchsin aldehyde \>>as conducted to observe changes in sellular structure.Changes in molecular level were observed by immunohystochemistry-approach with insulin, glucose transporter-4 telomerase and apoptosis antibody receptors. Results showed that vanadyl sulphate can imporove the morphology of muscle, liver, adipose and /3-pancreas cells that were damaged in streptozotocin induced diabetes. Muscle cells showed significant increase in diameter and glicogen sorage also increased. Fatty cells in the liver also decrease and damage of fatty cells also decrease. These improvement were in correlation with the increase in the activity of insulin receptor and glucose transporter-4 caused by vanadyl sulphate medication
format Article
PeerReviewed
author Junaidi Khotib, NIDN. 0022107001
Debra Dorotea
Elisabet Kasih
Nur Palestin
Pharmasinta Putri H.
Imam Susilo
author_facet Junaidi Khotib, NIDN. 0022107001
Debra Dorotea
Elisabet Kasih
Nur Palestin
Pharmasinta Putri H.
Imam Susilo
author_sort Junaidi Khotib, NIDN. 0022107001
title Mekanisme Molekuler Antidiabetika Vanadil Sulfat
title_short Mekanisme Molekuler Antidiabetika Vanadil Sulfat
title_full Mekanisme Molekuler Antidiabetika Vanadil Sulfat
title_fullStr Mekanisme Molekuler Antidiabetika Vanadil Sulfat
title_full_unstemmed Mekanisme Molekuler Antidiabetika Vanadil Sulfat
title_sort mekanisme molekuler antidiabetika vanadil sulfat
publisher Universitas Airlangga
publishDate 2011
url http://repository.unair.ac.id/85392/1/C32.pdf
http://repository.unair.ac.id/85392/2/Validasi%20C-32.pdf
http://repository.unair.ac.id/85392/
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