EFEK PEMBERIAN EKSTRAK ETHANOL DAUN KELOR (Moringa oleifera) TERHADAP GAMBARAN HISTOPATOLOGI HEPAR MENCIT JANTAN YANG DIINDUKSI PARASETAMOL
This research aims was to observe liver histopathological features of mice toward the effect of Moringa oleifera leaves extract to reduce the damage of paracetamol administration. This research used 30 male mice aged 2-3 months with an average body weight of 20-30 grams and using completely rando...
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| Main Author: | |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Language: | Indonesian Indonesian Indonesian Indonesian |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://repository.unair.ac.id/89467/1/KKC%20KK%20KH%20246%20-%2019%20Ais%20e-Abstrak.pdf http://repository.unair.ac.id/89467/2/KKC%20KK%20KH%20246%20-%2019%20Ais%20e-Daftar%20isi.pdf http://repository.unair.ac.id/89467/3/KKC%20KK%20KH%20246%20-%2019%20Ais%20e-Daftar%20pustaka.pdf http://repository.unair.ac.id/89467/4/KKC%20KK%20KH%20246%20-%2019%20Ais%20e.pdf http://repository.unair.ac.id/89467/ http://lib.unair.ac.id |
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| Institution: | Universitas Airlangga |
| Language: | Indonesian Indonesian Indonesian Indonesian |
| Summary: | This research aims was to observe liver histopathological features of mice
toward the effect of Moringa oleifera leaves extract to reduce the damage of
paracetamol administration. This research used 30 male mice aged 2-3 months
with an average body weight of 20-30 grams and using completely randomized
design (CRD) method with 5 repetitions for each groups. The negative control
group was given 0.5% CMC Na and distilled water, the positive control was
given 0.5% CMC Na and paracetamol, while treatments group one, two, and
three were given Moringa leaf extract at a dose of 200 mg / kg, 400 mg / kg, 800
mg/kg respectively, then administered paracetamol. At the end of the research,
mice are euthanized then liver collection was carried out. The liver collected was
made into preparations using H.E staining to observe its histopathological
features. According to the results of statistical analysis, there were significant
differences (p <0.05) to the histopathological features of the liver in male mice
induced by paracetamol between treatment groups. From the results obtained, it
can be inferred that the right dose of Moringa oleifera leaves ethanol extract to
reduce liver damage due to administration of paracetamol in male mice are 400
mg/ kgBW. |
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