Mesucalophylloidin, a new isoprenylated 4-phenylcoumarin from Mesua calophylloides (Ridl.) Kosterm

A new isoprenylated 4-phenylcoumarin derivative, mesucalophylloidin (1) along with three known compounds, mammea A/BA cyclo F (2), calolongic acid (3) and isocalolongic acid (4) were isolated from the stem bark of Mesua calophylloides (Ridl.) Kosterm. Structures of all the compounds were elucidated...

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Main Authors: Mulyadi Tanjung, Fida Rachmadiarti, Ratih Dewi Saputri, Tjitjik Srie Tjahjandarie
Format: Article PeerReviewed
Language:English
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Published: Taylor & Francis Online 2018
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Online Access:http://repository.unair.ac.id/90963/1/C.04.%20Abstract.pdf
http://repository.unair.ac.id/90963/2/C.04.%20Fulltext%20%28Karya%20Ilmiah%29.pdf
http://repository.unair.ac.id/90963/3/C04_Validasi_Mesucalophylloidin%2C%20a%20new%20isoprenylated.pdf
http://repository.unair.ac.id/90963/4/C04_Similarity.pdf
http://repository.unair.ac.id/90963/
https://www.tandfonline.com/doi/abs/10.1080/14786419.2017.1378215
https://doi.org/10.1080/14786419.2017.1378215
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Institution: Universitas Airlangga
Language: English
English
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Summary:A new isoprenylated 4-phenylcoumarin derivative, mesucalophylloidin (1) along with three known compounds, mammea A/BA cyclo F (2), calolongic acid (3) and isocalolongic acid (4) were isolated from the stem bark of Mesua calophylloides (Ridl.) Kosterm. Structures of all the compounds were elucidated using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1–4 were evaluated for their cytotoxicity against P-388 cells, showing that compound 1 gave moderate activity with IC 50 6.26 μg/mL.