High-Calorie Diet Reduces Neuroglia Count

• Main Authors: Nilam Anggraeni, Kristanti Wanito Wigati, Indrayuni Lukitra Wardani
• Format: Book Section PeerReviewed
• Language: English; English; English
• Published: Scitepress 2017
• Subjects: R Medicine (General); RA Public aspects of medicine
• Online Access: http://repository.unair.ac.id/96822/1/Bukti%20C.28%20-%20Copy.pdf; http://repository.unair.ac.id/96822/2/Peer%20Review%2029.pdf; http://repository.unair.ac.id/96822/3/High-Calorie%20Diet%20Reduces%20Neuroglia%20Count_compressed.pdf; http://repository.unair.ac.id/96822/; https://www.scitepress.org/PublicationsDetail.aspx?ID=0KQLACUAFX0=&t=1
• Institution: Universitas Airlangga

Abstract: Nowadays, high-calorie food consumption people can unwittingly affect health. Several studies have reported the effects of excesshigh-calorie food consumption can range fromhyperglycaemia to neurodegenerative interference. In the brain, astrocytes function to respond to the changing modificationof molecular brain environment.structure. This study aimed to observe the effect of a high-calorie diet on the brain histology of male mice (Mus musculus). In this study, 28 mice were randomly divided into 4 groups: the control group pre (K0); the control group post with a standard diet (K1) ;the treatment group with 0.15g of glucose diet (K2); and the treatment group with 0.25g of glucose diet (K3). Treatment was given everyday for eightweeks. Brains were then histologically processed and stained with Haematoxylin-Eosin (HE) and observation made of quantitative changes of astrocytes in the cerebral cortex. Results: Data were analyzed with Post-Hoc ANOVA. From the study, significant d ifferences were found between K0 and K2 (α <0.05). In addition, significant differences were obtained in the groups K0 and K3 (α <0.05). Meanwhile, no significant differences were found between groups (α> 0.05). In conclusion, a high-calorie diet affects thee brain histology of male mice.