Cytotoxic Carbazole Alkaloid from the Root of Clausena cxcavata on Hela Cell L

Cytotoxic Carbazole Alkaloid from the Root of Clausena cxcavata on Hela Cell L

In a search for bioactive constituents from Myanmar medicinal plants, a carbazole alkaloid, named 7hydroxy heptaphylline (1) was isolated from the root of Clausena excavata. The structure of isolated compound was elucidated based on spectrophotometric data such as UV-vis, FT-IR, NMR and HRMS data. T...

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Bibliographic Details
Main Authors: Tin Myo Thant, Nanik Siti Aminah, Alfinda Novi Kristanti, Rico Ramadhan, Hnin Thanda Aung, Yoshiaki Takaya
Format: Book Section PeerReviewed
Language:English
English
English
English
Published: Department Of Chemistry Universitas Sumatera Utara 2019
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://repository.unair.ac.id/98069/1/C30.%20Abstract.pdf
http://repository.unair.ac.id/98069/2/C30.%20Fulltext_Cytotoxic%20Carbazole%20_TIN_SCITEPRESS%202019.pdf
http://repository.unair.ac.id/98069/3/C30.%20Peereview1%20Prosiding.pdf
http://repository.unair.ac.id/98069/4/C30.%20Similarity%2025%25_Cytotoxic%20Carbazole%20Alkaloid%20from....pdf
http://repository.unair.ac.id/98069/
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Institution: Universitas Airlangga
Language: English
English
English
English
Description
Summary:In a search for bioactive constituents from Myanmar medicinal plants, a carbazole alkaloid, named 7hydroxy heptaphylline (1) was isolated from the root of Clausena excavata. The structure of isolated compound was elucidated based on spectrophotometric data such as UV-vis, FT-IR, NMR and HRMS data. The cytotoxicity of the isolated compound (1) was evaluated by MTT assay against on HeLa cancer cells. The compound (1) exhibited moderate inhibition activity with IC50 41.4 µg/ml.

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