Cytotoxic Carbazole Alkaloid from the Root of Clausena cxcavata on Hela Cell L

• Main Authors: Tin Myo Thant, Nanik Siti Aminah, Alfinda Novi Kristanti, Rico Ramadhan, Hnin Thanda Aung, Yoshiaki Takaya
• Format: Book Section PeerReviewed
• Language: English; English; English; English
• Published: Department Of Chemistry Universitas Sumatera Utara 2019
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://repository.unair.ac.id/98069/1/C30.%20Abstract.pdf; http://repository.unair.ac.id/98069/2/C30.%20Fulltext_Cytotoxic%20Carbazole%20_TIN_SCITEPRESS%202019.pdf; http://repository.unair.ac.id/98069/3/C30.%20Peereview1%20Prosiding.pdf; http://repository.unair.ac.id/98069/4/C30.%20Similarity%2025%25_Cytotoxic%20Carbazole%20Alkaloid%20from....pdf; http://repository.unair.ac.id/98069/
• Institution: Universitas Airlangga

In a search for bioactive constituents from Myanmar medicinal plants, a carbazole alkaloid, named 7hydroxy heptaphylline (1) was isolated from the root of Clausena excavata. The structure of isolated compound was elucidated based on spectrophotometric data such as UV-vis, FT-IR, NMR and HRMS data. The cytotoxicity of the isolated compound (1) was evaluated by MTT assay against on HeLa cancer cells. The compound (1) exhibited moderate inhibition activity with IC50 41.4 µg/ml.