UJI AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI AIR EKSTRAK ETANOLIK DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr.) PADA TIKUS JANTAN YANG DIINDUKSI DIET LEMAK TINGGI

Cardiovascular disease especially coronary heart disease (CHD) and stroke is the main killer in Indonesia. Atherosclerosis is the main cause of CHD. Hyperlipidemia is the main factor causing atherosclerosis. Indonesia is rich in medicinal plants, with various benefits. Sambung nyawa leaves (Gynura p...

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Main Authors: , Irfan Muris Setiawan, , Dr. Ika Puspita Sari, M.Si., Apt.
Format: Theses and Dissertations NonPeerReviewed
Published: [Yogyakarta] : Universitas Gadjah Mada 2012
Subjects:
ETD
Online Access:https://repository.ugm.ac.id/100909/
http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=57767
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spelling id-ugm-repo.1009092016-03-04T08:47:13Z https://repository.ugm.ac.id/100909/ UJI AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI AIR EKSTRAK ETANOLIK DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr.) PADA TIKUS JANTAN YANG DIINDUKSI DIET LEMAK TINGGI , Irfan Muris Setiawan , Dr. Ika Puspita Sari, M.Si., Apt. ETD Cardiovascular disease especially coronary heart disease (CHD) and stroke is the main killer in Indonesia. Atherosclerosis is the main cause of CHD. Hyperlipidemia is the main factor causing atherosclerosis. Indonesia is rich in medicinal plants, with various benefits. Sambung nyawa leaves (Gynura procumbens (Lour.) Merr.) are usually used as antihyperlipidemic agent. The objectives of this study are to evaluate water fraction of extract ethanolic of sambung nyawa leaves (FAES) as antihyperlipidemic agent and investigate its mechanism as lipase inhibitors. Antihyperlipidemic activity assay of FAES was conducted on high fat diet induced rats. High fat diet consisted of pellet: lard: egg yolk (80:15:5). High fat diet was given for 30 days. There are 7 groups of rats i.e. normal group, negative (water) group, negative (Na-CMC), FAES at dose 36,5 mg/kg, FAES 73 mg/kg, FAES 146 mg/kg, and positive control group. Total cholesterol, triglyceride, HDL cholesterol, and LDL cholesterol were measured at day 0, 30, and 45, meanwhile lipase activity was measured at days 30 and 45. The results demonstrated that FAES contain polyphenol and flavonoid as much as 2,42+ 0,05 % and 1,51 + 0,01% respectively. Administration FAES for 15 days at dose 36.5 mg/kg, 73 mg/kg, and 146 mg/kg decreased total cholesterol level as 21.38+3.09 % [Yogyakarta] : Universitas Gadjah Mada 2012 Thesis NonPeerReviewed , Irfan Muris Setiawan and , Dr. Ika Puspita Sari, M.Si., Apt. (2012) UJI AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI AIR EKSTRAK ETANOLIK DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr.) PADA TIKUS JANTAN YANG DIINDUKSI DIET LEMAK TINGGI. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=57767
institution Universitas Gadjah Mada
building UGM Library
country Indonesia
collection Repository Civitas UGM
topic ETD
spellingShingle ETD
, Irfan Muris Setiawan
, Dr. Ika Puspita Sari, M.Si., Apt.
UJI AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI AIR EKSTRAK ETANOLIK DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr.) PADA TIKUS JANTAN YANG DIINDUKSI DIET LEMAK TINGGI
description Cardiovascular disease especially coronary heart disease (CHD) and stroke is the main killer in Indonesia. Atherosclerosis is the main cause of CHD. Hyperlipidemia is the main factor causing atherosclerosis. Indonesia is rich in medicinal plants, with various benefits. Sambung nyawa leaves (Gynura procumbens (Lour.) Merr.) are usually used as antihyperlipidemic agent. The objectives of this study are to evaluate water fraction of extract ethanolic of sambung nyawa leaves (FAES) as antihyperlipidemic agent and investigate its mechanism as lipase inhibitors. Antihyperlipidemic activity assay of FAES was conducted on high fat diet induced rats. High fat diet consisted of pellet: lard: egg yolk (80:15:5). High fat diet was given for 30 days. There are 7 groups of rats i.e. normal group, negative (water) group, negative (Na-CMC), FAES at dose 36,5 mg/kg, FAES 73 mg/kg, FAES 146 mg/kg, and positive control group. Total cholesterol, triglyceride, HDL cholesterol, and LDL cholesterol were measured at day 0, 30, and 45, meanwhile lipase activity was measured at days 30 and 45. The results demonstrated that FAES contain polyphenol and flavonoid as much as 2,42+ 0,05 % and 1,51 + 0,01% respectively. Administration FAES for 15 days at dose 36.5 mg/kg, 73 mg/kg, and 146 mg/kg decreased total cholesterol level as 21.38+3.09 %
format Theses and Dissertations
NonPeerReviewed
author , Irfan Muris Setiawan
, Dr. Ika Puspita Sari, M.Si., Apt.
author_facet , Irfan Muris Setiawan
, Dr. Ika Puspita Sari, M.Si., Apt.
author_sort , Irfan Muris Setiawan
title UJI AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI AIR EKSTRAK ETANOLIK DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr.) PADA TIKUS JANTAN YANG DIINDUKSI DIET LEMAK TINGGI
title_short UJI AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI AIR EKSTRAK ETANOLIK DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr.) PADA TIKUS JANTAN YANG DIINDUKSI DIET LEMAK TINGGI
title_full UJI AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI AIR EKSTRAK ETANOLIK DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr.) PADA TIKUS JANTAN YANG DIINDUKSI DIET LEMAK TINGGI
title_fullStr UJI AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI AIR EKSTRAK ETANOLIK DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr.) PADA TIKUS JANTAN YANG DIINDUKSI DIET LEMAK TINGGI
title_full_unstemmed UJI AKTIVITAS ANTIHIPERLIPIDEMIA FRAKSI AIR EKSTRAK ETANOLIK DAUN SAMBUNG NYAWA (Gynura procumbens (Lour.) Merr.) PADA TIKUS JANTAN YANG DIINDUKSI DIET LEMAK TINGGI
title_sort uji aktivitas antihiperlipidemia fraksi air ekstrak etanolik daun sambung nyawa (gynura procumbens (lour.) merr.) pada tikus jantan yang diinduksi diet lemak tinggi
publisher [Yogyakarta] : Universitas Gadjah Mada
publishDate 2012
url https://repository.ugm.ac.id/100909/
http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=57767
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