HUBUNGAN PSORIASIS VULGARIS DAN TUMOR NECROSIS FACTOR-α DENGAN SINDROMMETABOLIK
Psoriasis vulgaris is chronic inflammatoryskin disease which mediated by T cell and proinflammatory cytokines. Proinflammatory cytokines especially TNF-α and IL-6 exert systemic effects on insulin resistance. Insulin resistance is basic pathophysiology of metabolic syndrome. Metabolic syndrome is t...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/119909/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=59915 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Psoriasis vulgaris is chronic inflammatoryskin disease which mediated by
T cell and proinflammatory cytokines. Proinflammatory cytokines especially
TNF-α and IL-6 exert systemic effects on insulin resistance. Insulin resistance is
basic pathophysiology of metabolic syndrome. Metabolic syndrome is the risk of
individual cardiometabolic diseasewhich include abdominal obesity,
dyslipidemia, hypertension and elevated blood glucose.
The objective of this study was to investigate the association between
psoriasis vulgaris and metabolic syndrome. A cross-sectional study was done
among 40 psoriasis vulgaris patients and 40 non psoriatic healthy subjects
visiting outpatient Department of Dermatology and Venereology clinic Dr.
Sardjito hospital, Yogyakarta. Blood pressure, fasting bood glucose, HDL
cholesterol, waist circumference, triglycerides and TNF-α were examined.
Metabolic syndrome was found in 35% psoriatic patients compared to 15
% in non-psoriatic patients(RR 2,33 |
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