HUBUNGAN PSORIASIS VULGARIS DAN TUMOR NECROSIS FACTOR-α DENGAN SINDROMMETABOLIK

• Main Authors: , Yuni Lidya, , Prof. Dr.dr. Hardyanto Soebono, SpKK(K)
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2013
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/119909/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=59915
• Institution: Universitas Gadjah Mada

Psoriasis vulgaris is chronic inflammatoryskin disease which mediated by T cell and proinflammatory cytokines. Proinflammatory cytokines especially TNF-α and IL-6 exert systemic effects on insulin resistance. Insulin resistance is basic pathophysiology of metabolic syndrome. Metabolic syndrome is the risk of individual cardiometabolic diseasewhich include abdominal obesity, dyslipidemia, hypertension and elevated blood glucose. The objective of this study was to investigate the association between psoriasis vulgaris and metabolic syndrome. A cross-sectional study was done among 40 psoriasis vulgaris patients and 40 non psoriatic healthy subjects visiting outpatient Department of Dermatology and Venereology clinic Dr. Sardjito hospital, Yogyakarta. Blood pressure, fasting bood glucose, HDL cholesterol, waist circumference, triglycerides and TNF-α were examined. Metabolic syndrome was found in 35% psoriatic patients compared to 15 % in non-psoriatic patients(RR 2,33