KORELASI ANTARA KADAR FERITIN SERUM DAN FUNGSI KOGNITIF PADA ANAK DENGAN THALASSEMIA MAYOR
Cognitive abnormalities in thalassemia major is controversial and hypothetically related to chronic anemia and high levels of serum ferritin. High serum ferritin can go through blood brain barrier by unclear mechanisms and may cause impaired cognitive function by neurogeneration from iron free radic...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/120591/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=60629 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Cognitive abnormalities in thalassemia major is controversial and
hypothetically related to chronic anemia and high levels of serum ferritin. High
serum ferritin can go through blood brain barrier by unclear mechanisms and may
cause impaired cognitive function by neurogeneration from iron free radicals.
Objective : To determine the correlation between serum ferritin levels and
cognitive function in thalassemia major children.
Methods : Cross-sectional design. Subjects were children with thalassemia major
aged 5-<16 years old. Ferritin measurements performed by ELFA and cognitive
function by WISC test.
Results : Sixty three children was included. Abnormal value in verbal IQ were
36.5%, performance IQ were 46.0% and full IQ were 46.0%. Mean serum ferritin
level was 4082.13 (+3141.71) μg/L. There was correlation between serum ferritin
levels and performance IQ (r = -0.284, p = 0.024), but no significant correlation
with verbal IQ (r = -0.034, p = 0.789) and a full IQ (r = - 0.165, p = 0.195).
Multivariate linear regression analysis showed, variables which have contribution
in performance IQ were serum ferritin levels (β = -0.001, p = 0.011, 95% CI -
0.003 to -0.0003), frequency of transfusions (β = 8.969, p = 0.021, 95% CI 1.387
to 16.550), and children�s educational status (β = 15.816, p = 0.023, 95% CI 2.222
to 29.410). Children�s educational status was correlated with full IQ (β = 18.038,
p = 0.018, 95% CI 3.242 to 32.834).
Conclusions : High serum ferritin level correlated with low cognitive function in
thalassemia major children specifically in performance IQ. |
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