KORELASI ANTARA KADAR FERITIN SERUM DAN FUNGSI KOGNITIF PADA ANAK DENGAN THALASSEMIA MAYOR

• Main Authors: , HASTUTI INDRA RETNANI, , Prof. dr. Djauhar Ismail, MPH, Ph.D, Sp.A.(K)
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2013
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/120591/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=60629
• Institution: Universitas Gadjah Mada

Cognitive abnormalities in thalassemia major is controversial and hypothetically related to chronic anemia and high levels of serum ferritin. High serum ferritin can go through blood brain barrier by unclear mechanisms and may cause impaired cognitive function by neurogeneration from iron free radicals. Objective : To determine the correlation between serum ferritin levels and cognitive function in thalassemia major children. Methods : Cross-sectional design. Subjects were children with thalassemia major aged 5-<16 years old. Ferritin measurements performed by ELFA and cognitive function by WISC test. Results : Sixty three children was included. Abnormal value in verbal IQ were 36.5%, performance IQ were 46.0% and full IQ were 46.0%. Mean serum ferritin level was 4082.13 (+3141.71) μg/L. There was correlation between serum ferritin levels and performance IQ (r = -0.284, p = 0.024), but no significant correlation with verbal IQ (r = -0.034, p = 0.789) and a full IQ (r = - 0.165, p = 0.195). Multivariate linear regression analysis showed, variables which have contribution in performance IQ were serum ferritin levels (β = -0.001, p = 0.011, 95% CI - 0.003 to -0.0003), frequency of transfusions (β = 8.969, p = 0.021, 95% CI 1.387 to 16.550), and children�s educational status (β = 15.816, p = 0.023, 95% CI 2.222 to 29.410). Children�s educational status was correlated with full IQ (β = 18.038, p = 0.018, 95% CI 3.242 to 32.834). Conclusions : High serum ferritin level correlated with low cognitive function in thalassemia major children specifically in performance IQ.