PENGARUH PEMBERIAN TEPUNG GEMBILI (Dioscorea esculenta) TERHADAP GLUKOSA DARAH TIKUS WISTAR YANG DIINDUKSI NIKOTINAMIDE DAN STREPTOZOTOSIN
Background: Diabetes mellitus is a metabolic diseases that characterized by hyperglycemia which result of defects in insulin secretion, insulin action, or both. Data from WHO showed that prevalention of diabetes extremely increase in the some countries included Indonesia. The easy prevention and the...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/121991/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=62090 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Background: Diabetes mellitus is a metabolic diseases that characterized by
hyperglycemia which result of defects in insulin secretion, insulin action, or both.
Data from WHO showed that prevalention of diabetes extremely increase in the
some countries included Indonesia. The easy prevention and therapy action is
dietary modification with high fibre and Resistant Starch (RS) diet. Physiological
characteristic of fibre and RS, and their metabolism on human colon can help
glycemic control. Gembili (Dioscorea esculenta) is the one of high fibre and RS
food that possible to help glycemic control.
Objective: The aim of this study was to assess the effect of gembili powder
(Dioscorea esculenta) on glucose level of wistar rats induced by nicotinamide and
streptozotocin.
Method: Experimental study was used as a design in this study. Twenty five (25)
male Wistar rats aged 2 month were used in this study. Rats was devided into
five groups. Group one is healthy control group, group two is hiperglycemia
control group, and group three-five is treatment groups. Hiperglycemic control
groups and treatment groups was induced with Nicotinamide and Streptozotocin
before treatment to make hiperglycemia condition. The treatment groups was
given gembili powder 1,25 g, 250 g, and 5,00 g each day. Glucose test was doing
before treatment, 2 week after treatment and 4 week after treatment.
Result: The significant decrease of glucose level was occur on 1,25 g and 2,50 g
gembili powder treatment with p value 0,001 and 0,002. Highest decrease
glucose level was happen on 2,50 g gembili powder perday treatment.
Conclusion: 1,25 gr and 2,50 gr Gembili powder (Dioscorea esculenta) perday
treatment could decrease glucose level on Nicotinamide and Streptozotocin
Induced Rats |
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