PENGARUH PEMBERIAN JUS BUAH KERSEN (Muntingia calabura) TERHADAP KADAR TRIGLISERIDA PADA TIKUS SPRAGUE DAWLEY DISLIPIDEMIA
Background: Coronary heart disease is caused by the interruption of blood flow to the heart muscle because there is a narrowing of the coronary arteries or atherosclerosis. The cause of atherosclerosis is dyslipidemia. One of the abnormalities dyslipidemia is hypertriglyceridemia. Antioxidants play...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/122022/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=62121 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Background: Coronary heart disease is caused by the interruption of blood flow
to the heart muscle because there is a narrowing of the coronary arteries or
atherosclerosis. The cause of atherosclerosis is dyslipidemia. One of the
abnormalities dyslipidemia is hypertriglyceridemia. Antioxidants play a role in
dealing hypertriglyceridemia. One type of antioxidant is vitamin C. Vitamin C can
reduce hypertriglyceridemia with different mechanisms. One of the fruits that rich
vitamin C are cherry (Muntingia calabura). Thus conducted this study on the
influence of fruit cherry (Muntingia calabura) on the incidence of dyslipidemia,
especially its effect on blood triglyceride levels.
Objective: To determine the effect of cherry juice (Muntingia calabura) to
triglyceride of Sprague Dawley rats dyslipidemia.
Methods: This research is a quasi experimental study with pretest and posttest
control group design. 25 rats were divided into 5 groups underwent an adaptation
period of 7 days (pre-test), a high-fat diet period of 5 weeks (mid-test) and the
treatment period of 2 weeks (post-test). At the treatment period, rat divided into 5
groups, K1, K2, K3, K4 and K5. K1/diseased control treated with the standard
feed and distilled water, K2 treated with the standard feed and cherry juice dose
1 (1,15 g/mL/200 g rat weight), and K3 treated with the standard feed and cherry
juice dose 2 (2,3 g/mL/200 g rat weight), K4 treated with high fat diet and cherry
juice dose 2 (2,3 g/mL/200 g rat weight), and K5/normal control treated with the
standard feed and distilled water. The data were analized with One Way ANOVA
and Paired Sample T test after normalized data with Saphiro Wilk test.
Results: There was a significant weight gain in all groups at week giving a highfat
diet (p<0,05) and tended to decline during the administration cherry fruit juices
especially the K2, K3, and K5. There is no significant difference in feed intake in
all groups except in the 3rd week of giving high-fat diet (p<0,05). There is the
effect of high-fat diet on levels of triglycerides mid test (p<0,05) although the
increase is not significant (p>0,05). There is no treatment effect on triglyceride
levels post-test (p>0,05) despite a significant decrease in all groups (p<0,05).
Conclusion: The fruit juice cherry (Muntingia calabura) can decrease triglyceride
levels of Sprague Dawley rats dyslipidemia |
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