PENGARUH PEMBERIAN CAMPURAN EKSTRAK ETANOL Tithonia diversifolia (HEMSLEY) A.GRAY DAN Curcuma domestica VAL TERHADAP BERAT BADAN DAN NODUL TIKUS BETINA MODEL KANKER PAYUDARA
Background: Kembang bulan [Tithonia diversifolia (Hemsley) A. Gray] is an anticancer drug candidate plants that have been previously shown have cytotoxics effect on colon cancer cells (WiDr), IC=61.55ug/ml. Turmeric rhizome (Curcuma domestica Val.) is widely used in traditional medicine. Curcuminoid...
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| Main Authors: | , |
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| Format: | Theses and Dissertations NonPeerReviewed |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| Subjects: | |
| Online Access: | https://repository.ugm.ac.id/123091/ http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=63202 |
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| Institution: | Universitas Gadjah Mada |
| Summary: | Background: Kembang bulan [Tithonia diversifolia
(Hemsley) A. Gray] is an anticancer drug candidate
plants that have been previously shown have cytotoxics
effect on colon cancer cells (WiDr), IC=61.55ug/ml.
Turmeric rhizome (Curcuma domestica Val.) is widely
used in traditional medicine. Curcuminoids compounds
from turmeric have potential anticancer activity
against adenomous with possibly modulate immune
function mediated by lymphocytes. With the
immunostimulatory effect of turmeric extracts when
mixed with kembang bulan extracts as a candidate
anticancer is expected to add to the improvement of
future cancer patients.
Objectives: To determine the potential of mixture
ethanol extract of T. diversifolia and C. domestica in
animal models of breast cancer by measuring weight,
number of nodules, and nodule volume animals.
Methods: The study was a quasi-experimental study.
Mixed 70% ethanol extract of kembang bulan�s leaves and
turmeric�s rhizome divided into 3 doses, 40mg, 80mg,
and 160mg. Then it given to each group of rats that had
experienced breast cancer. After that, see potential on
body weight, number of nodules, and nodule volume. Then
compared with normal group, negative control group, and
positive control group. Furthermore, the percentage
change in each treatment group were compared and
statistically tested using ANOVA analysis.
Results: Comparison of the results of rat�s body weight
between the control group (doxorubicin) and test group
showed significantly no different results. Comparison
of the results of rat�s breast cancer nodule volume
between the control group and the test group showed
significantly different results.
Conclusion: A mixture of 70% ethanol extract of kembang
bulan�s leaves and turmeric�s rhizome have no
significant effect on body weight sum of nodules, and
have significant effet on breast cancer nodules volume. |
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