PENGARUH PEMBERIAN CAMPURAN EKSTRAK ETANOL Tithonia diversifolia (HEMSLEY) A.GRAY DAN Curcuma domestica VAL TERHADAP BERAT BADAN DAN NODUL TIKUS BETINA MODEL KANKER PAYUDARA

• Main Authors: , WAHYU NUR HALIMAH, , Prof. Dr. Mae Sri Hartati Wahyuningsih, M.Si., Apt.
• Format: Theses and Dissertations NonPeerReviewed
• Published: [Yogyakarta] : Universitas Gadjah Mada 2013
• Subjects: ETD
• Online Access: https://repository.ugm.ac.id/123091/; http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=63202
• Institution: Universitas Gadjah Mada

Background: Kembang bulan [Tithonia diversifolia (Hemsley) A. Gray] is an anticancer drug candidate plants that have been previously shown have cytotoxics effect on colon cancer cells (WiDr), IC=61.55ug/ml. Turmeric rhizome (Curcuma domestica Val.) is widely used in traditional medicine. Curcuminoids compounds from turmeric have potential anticancer activity against adenomous with possibly modulate immune function mediated by lymphocytes. With the immunostimulatory effect of turmeric extracts when mixed with kembang bulan extracts as a candidate anticancer is expected to add to the improvement of future cancer patients. Objectives: To determine the potential of mixture ethanol extract of T. diversifolia and C. domestica in animal models of breast cancer by measuring weight, number of nodules, and nodule volume animals. Methods: The study was a quasi-experimental study. Mixed 70% ethanol extract of kembang bulan�s leaves and turmeric�s rhizome divided into 3 doses, 40mg, 80mg, and 160mg. Then it given to each group of rats that had experienced breast cancer. After that, see potential on body weight, number of nodules, and nodule volume. Then compared with normal group, negative control group, and positive control group. Furthermore, the percentage change in each treatment group were compared and statistically tested using ANOVA analysis. Results: Comparison of the results of rat�s body weight between the control group (doxorubicin) and test group showed significantly no different results. Comparison of the results of rat�s breast cancer nodule volume between the control group and the test group showed significantly different results. Conclusion: A mixture of 70% ethanol extract of kembang bulan�s leaves and turmeric�s rhizome have no significant effect on body weight sum of nodules, and have significant effet on breast cancer nodules volume.